Riboflavin-5-phosphate sodium

Base Information

• Chemical Name: Riboflavin-5-phosphate sodium
• CAS No.: 130-40-5
• Molecular Formula: C17H21 N4 O9 P . Na
• Molecular Weight: 478.331
• Hs Code.: 29362300
• Mol file: 130-40-5.mol

Synonyms:Riboflavin5'-(dihydrogen phosphate), monosodium salt (9CI);Riboflavine, 5'-phosphate, sodium salt(7CI);Alloxazine mononucleotide sodium salt;Coflavinase;Cytoflav;Hyryl;Riboflavin 5'-phosphate ester monosodium salt;Riboflavin monophosphate monosodium salt;Riboflavin sodium phosphate;Riboflavine monosodium 5'-phosphate;Riboflavinesodium phosphate;Sodium FMN;Sodium riboflavin-5'-phosphate;

Chemical Property of Riboflavin-5-phosphate sodium

Chemical Property:

• Appearance/Colour: solid
• Melting Point: >300°C
• Refractive Index: 41 ° (C=1.5, 5mol/L HCl)
• PSA: 220.73000
• LogP: -1.12000
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL, clear, orange
• Water Solubility.: almost transparency

Purity/Quality:

99%, ^*data from raw suppliers

RiboflavinPhosphateSodiumSalt(~70%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 22-24/25-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Description: Riboflavin-5-phosphate sodium (sodium FMN) consist mainly monosodium salt of Riboflavin 5-phophate (FMN), the 5-monophosphate ester of riboflavin. Riboflavin-5-phosphate sodium is produced by direct reaction of riboflavin with a phosphorylating agent such as phosphorous oxychloride in an organic solvent. Riboflavin 5-phophate (FMN) is essential as a coenzyme in various enzymic reactions in the body and is therefore used in the form of its salts, especially in the form of sodium FMN, as additive to drugs and human and animal food. Sodium FMN is also used as starting material for flavin adenine dinucleotide which is employed for treating vitamin B2 deficiency. It is used as a yellow food color additive (E106).? Riboflavin 5-phosphate sodium is fairly stable in air but is hygroscopic and sensitive to heat and light. The product may be stored for 33 months from the date of manufacture in the unopened original container and at a temperature below 15 °C.
• Uses: One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). antibacterial. Riboflavin 5′-monophosphate sodium salt was used as water-soluble model drug in a combined conventional inkjet printing technology with flexographic printing for the fabrication of drug delivery systems.It may be employed as initiator for the photo-initiated polymerization of acrylamide.It may be employed in chronoamperometric assay for vanadium ions. Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF).Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide. Riboflavin 5′-monophosphate sodium salt hydrate has been used:as a component of assay buffer to determine the luminescence of L. lactis cellsas a component of the reaction mixture in nitric oxide synthase (NOS) enzymatic activity assayin the high performance liquid chromatography (HPLC) analysis of Flavin mononucleotide (FMN) cyclase productsin luciferase assay with firefly luciferase
• Biological Functions: Riboflavin 5'-Phosphate Sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. Riboflavin phosphate sodium is converted to 2 coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are necessary for energy production by aiding in the metabolism of fats, carbohydrates and proteins and are required for red blood cell formation and respiration, antibody production and for regulating human growth and reproduction. Riboflavin phosphate sodium is essential for healthy skin, nails and hair growth.

Technology Process of Riboflavin-5-phosphate sodium

There total 2 articles about Riboflavin-5-phosphate sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

riboflavin (83-88-5,42880-33-1) → sodium riboflavin-5'-monophosphate (130-40-5)

Guidance literature:

riboflavin; With pyridine; water; trichlorophosphate; In acetonitrile; at 15 ℃; for 16h;

With hydrogenchloride; In water; at 50 ℃; for 6h;

With sodium hydroxide; In water; at 40 ℃; for 12h; pH=9;

Reference yield:

1,5-dihydroflavin → sodium riboflavin-5'-monophosphate (130-40-5)

Guidance literature:

With oxygen; In aq. phosphate buffer; at 24.84 ℃; for 0.166667h; pH=6; Kinetics; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201307273

Reference yield:

sodium riboflavin-5'-monophosphate (130-40-5) → flavin mononucleotide (5666-16-0)

Guidance literature:

With hydrogen; hydrogenase 1 from Escherichia coli; In aq. buffer; at 25 ℃; for 3.5h; under 750.075 Torr; pH=8; Glovebox; Sealed tube; Enzymatic reaction;

DOI:10.1002/anie.202101186

upstream raw materials:

riboflavin

Downstream raw materials:

flavin mononucleotide

Refernces

• 1、 -. "Production technology for riboflavin sodium phosphate". Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0053. . Retrieved 2017/10/31.
• 2、 -. "Synthesis method and process of riboflavin sodium phosphate". Paragraph 0015; 0016; 0017; 0018; 0019; 0020; 0021; 0022. . Retrieved 2017/01/17.