1,3-Diacetoxy-2-(acetoxymethoxy)propane

Base Information

• Chemical Name: 1,3-Diacetoxy-2-(acetoxymethoxy)propane
• CAS No.: 86357-13-3
• Molecular Formula: C10H16O7
• Molecular Weight: 248.233
• Hs Code.: 2915390090
• European Community (EC) Number: 617-837-8
• DSSTox Substance ID: DTXSID50430813
• Nikkaji Number: J1.139.901K
• Wikidata: Q72462493
• Mol file: 86357-13-3.mol

Synonyms:1,3-DIACETOXY-2-(ACETOXYMETHOXY)PROPANE;86357-13-3;2-(acetoxymethoxy)propane-1,3-diyl diacetate;[3-acetyloxy-2-(acetyloxymethoxy)propyl] acetate;2-acetoxymethoxy-1,3-diacetoxypropane;1,3-diacetoxy-2-propoxymethyl acetate;2-acetoxymethoxy-1,3-diacetoxy propane;1,3-Diacetoxy-2-(acetoxymethoxy)propan;2-ACETOXYMETHOXY-1,3-PROPANEDIOL DIACETATE;SCHEMBL2466001;DTXSID50430813;DUOPMEBLLUYTNT-UHFFFAOYSA-N;AMY17778;BCP17419;MFCD08457701;1,3-diacetoxy-2-acetoxymethoxypropane;AKOS015841105;SB67311;AC-23926;AS-15399;acetoxymethyl 1,3-diacetoxy-2-propyl ether;CS-0155002;FT-0659911;2-(Acetoxymethoxy)-1,3-propanediyl diacetate;A841613

Chemical Property of 1,3-Diacetoxy-2-(acetoxymethoxy)propane

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.439
• Boiling Point: 310.901 °C at 760 mmHg
• Flash Point: 133.59 °C
• PSA: 88.13000
• Density: 1.178 g/cm³
• LogP: 0.01840
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 248.08960285
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC(COC(=O)C)OCOC(=O)C

Technology Process of 1,3-Diacetoxy-2-(acetoxymethoxy)propane

There total 7 articles about 1,3-Diacetoxy-2-(acetoxymethoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(chloromethoxy)-1,3-dichloropropane (53883-86-6) + potassium acetate (127-08-2) → 2-(acetoxymethoxy)-1,3-propanediyl diacetate (86357-13-3)

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1055/s-1999-6058

Reference yield: 63.0%

2-(chloromethoxy)-1,3-dichloropropane (53883-86-6) + sodium acetate (127-09-3) → 2-(acetoxymethoxy)-1,3-propanediyl diacetate (86357-13-3)

Guidance literature:

In N,N-dimethyl-formamide; 1.)140 deg C, 6 h 2.)20 deg C, 18 h;

DOI:10.1007/BF00473325

Reference yield: 37.5%

→ 2-(acetoxymethoxy)-1,3-propanediyl diacetate (86357-13-3)

Guidance literature:

upstream raw materials:

2-(chloromethoxy)-1,3-dichloropropane

sodium acetate

2-(methoxymethoxy)-1,3-propanediyl diacetate

acetic anhydride

Downstream raw materials:

9-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine

7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine

RP-170

1,2,3,5-tetraacetylribose

Refernces

• 1、 -. "Syntheses of acyclic guanine nucleosides". . . Retrieved 2008/06/13.
• 2、 -. "Anti-viral guanine compounds". . . Retrieved 2008/06/13.