10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate

Base Information

• Chemical Name: 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate
• CAS No.: 1207984-77-7
• Molecular Formula: C₂HF₃O₂*C₂₃H₂₄N₆O₂
• Molecular Weight: 530.507
• Mol file: 1207984-77-7.mol

Synonyms:10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate

Chemical Property of 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate

There total 7 articles about 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione (1207984-80-2) + Cyclopropylamine (765-30-0) + trifluoroacetic acid (76-05-1) → 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate (1207984-77-7)

Guidance literature:

10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione; Cyclopropylamine; In dimethyl sulfoxide; at 70 ℃; for 48h;

trifluoroacetic acid;

Reference yield:

3-chloro-p-toluidine (95-74-9,827571-80-2) → 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate (1207984-77-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dmap; triethylamine / ethyl acetate / 6 h / 0 - 20 °C

2.1: nitric acid; acetic anhydride / acetic acid / 5 h / -10 - 20 °C

3.1: methanol; sodium methylate / 5 h / 20 °C

4.1: ammonium chloride / ethanol / Reflux; Inert atmosphere

5.1: sodium tetrahydroborate / ethanol / 12 h / Reflux

5.2: 0 - 20 °C

6.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere

7.1: sulfuric acid; periodic acid / water / 0 - 20 °C

7.2: pH 3.8 - 3.9

8.1: acetic acid / ethanol / 20 - 40 °C

8.2: 2 h / 20 °C

9.1: dimethyl sulfoxide / 48 h / 70 °C

With methanol; dmap; boron trioxide; sodium tetrahydroborate; sulfuric acid; nitric acid; sodium methylate; acetic anhydride; ammonium chloride; acetic acid; periodic acid; triethylamine; In ethanol; water; acetic acid; dimethyl sulfoxide; ethyl acetate;

Reference yield:

5-chloro-4-methyl-2-nitroacetanilide (7149-78-2) → 10-(2-(benzylamino)ethyl)-8-(cyclopropylamino)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione 2,2,2-trifluoroacetate (1207984-77-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: methanol; sodium methylate / 5 h / 20 °C

2.1: ammonium chloride / ethanol / Reflux; Inert atmosphere

3.1: sodium tetrahydroborate / ethanol / 12 h / Reflux

3.2: 0 - 20 °C

4.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere

5.1: sulfuric acid; periodic acid / water / 0 - 20 °C

5.2: pH 3.8 - 3.9

6.1: acetic acid / ethanol / 20 - 40 °C

6.2: 2 h / 20 °C

7.1: dimethyl sulfoxide / 48 h / 70 °C

With methanol; boron trioxide; sodium tetrahydroborate; sulfuric acid; sodium methylate; ammonium chloride; acetic acid; periodic acid; In ethanol; water; dimethyl sulfoxide;

upstream raw materials:

10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione

Cyclopropylamine

trifluoroacetic acid

(8-chloro-7-methyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-acetaldehyde

Refernces