Technology Process of 10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione
There total 7 articles about 10-(2-(benzylamino)ethyl)-8-chloro-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(8-chloro-7-methyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-acetaldehyde; benzylamine;
With
acetic acid;
In
ethanol;
at 20 - 40 ℃;
With
sodium cyanoborohydride;
In
ethanol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dmap; triethylamine / ethyl acetate / 6 h / 0 - 20 °C
2.1: nitric acid; acetic anhydride / acetic acid / 5 h / -10 - 20 °C
3.1: methanol; sodium methylate / 5 h / 20 °C
4.1: ammonium chloride / ethanol / Reflux; Inert atmosphere
5.1: sodium tetrahydroborate / ethanol / 12 h / Reflux
5.2: 0 - 20 °C
6.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere
7.1: sulfuric acid; periodic acid / water / 0 - 20 °C
7.2: pH 3.8 - 3.9
8.1: acetic acid / ethanol / 20 - 40 °C
8.2: 2 h / 20 °C
With
methanol; dmap; boron trioxide; sodium tetrahydroborate; sulfuric acid; nitric acid; sodium methylate; acetic anhydride; ammonium chloride; acetic acid; periodic acid; triethylamine;
In
ethanol; water; acetic acid; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere
2.1: sulfuric acid; periodic acid / water / 0 - 20 °C
2.2: pH 3.8 - 3.9
3.1: acetic acid / ethanol / 20 - 40 °C
3.2: 2 h / 20 °C
With
boron trioxide; sulfuric acid; acetic acid; periodic acid;
In
ethanol; water;