(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

Base Information Edit

Chemical Name:(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
CAS No.:106939-34-8
Molecular Formula:C15H13F2NO4
Molecular Weight:309.269
Hs Code.:2934999090
European Community (EC) Number:691-244-2
DSSTox Substance ID:DTXSID00356837
Nikkaji Number:J2.015.006H
Mol file:106939-34-8.mol

Synonyms:106939-34-8;(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate;(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester;LEVOFLOXACIN ACID ESTER;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-, ethyl ester, (3S)-;EC 691-244-2;ethyl (2S)-6,7-difluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylate;C15H13F2NO4;(3S)-9,10-Difluoro-2,3-dihidro-3-metil-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxacine-6-carboxilic acid ethyl ester;(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid E;Levofloxacin Impurity 10;MFCD09030626;SCHEMBL2339241;DTXSID00356837;AKOS015896240;AC-8096;CS-W007121;AS-14000;ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate;F19510;A895724;J-001679;7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;(S)-Ethyl9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate;3alpha-Methyl-7-oxo-9,10-difluoro-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester;Ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

Suppliers and Price of (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcidEthylEster
2g
$ 240.00

Medical Isotopes, Inc.
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcidEthylEster
1 g
$ 590.00

Matrix Scientific
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 95+%
5g
$ 756.00

Matrix Scientific
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 95+%
1g
$ 284.00

Crysdot
(S)-Ethyl9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 97%
500g
$ 301.00

Biosynth Carbosynth
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
1 g
$ 185.00

Biosynth Carbosynth
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
500 mg
$ 125.00

Biosynth Carbosynth
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
10 g
$ 555.00

Biosynth Carbosynth
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
5 g
$ 375.00

Biosynth Carbosynth
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
2 g
$ 280.00

Total 110 raw suppliers

Chemical Property of (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate Edit

Chemical Property:

Appearance/Colour:off-white pale yellow solid
Vapor Pressure:5.11E-08mmHg at 25°C
Melting Point:258-260 °C
Refractive Index:1.582
Boiling Point:442.2 °C at 760 mmHg
PKA:-3.62±0.60(Predicted)
Flash Point:221.2 °C
PSA：57.53000
Density:1.43 g/cm³
LogP:2.40980
Storage Temp.:-20?C Freezer
Solubility.:Acetic Acid (Slightly), Chloroform (Slightly), Methanol (Slightly, Heated)
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:309.08126422
Heavy Atom Count:22
Complexity:524

Purity/Quality:

99% ^*data from raw suppliers

(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN2C(COC3=C2C(=CC(=C3F)F)C1=O)C
Isomeric SMILES:CCOC(=O)C1=CN2[C@H](COC3=C2C(=CC(=C3F)F)C1=O)C
Uses Levofloxacin intermediate

Technology Process of (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate

There total 16 articles about (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

: 2749-11-3
(S)-Alaninol

: 141-78-6
ethyl acetate

: 94695-48-4
2,3,4,5-tetrafluorobenzoyl chloride

: 109-94-4
formic acid ethyl ester

: 106939-34-8
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate

Guidance literature:: ethyl acetate; formic acid ethyl ester; With sodium hydride; In toluene;

(S)-Alaninol; 2,3,4,5-tetrafluorobenzoyl chloride; In toluene; at 20 ℃; Reflux;

With potassium fluoride; In N,N-dimethyl-formamide; Reflux;