2-Fluoro-4-methoxybenzyl chloride

Base Information

• Chemical Name: 2-Fluoro-4-methoxybenzyl chloride
• CAS No.: 331-63-5
• Molecular Formula: C8H8ClFO
• Molecular Weight: 174.602
• Hs Code.: 2909309090
• Mol file: 331-63-5.mol

Synonyms:Anisole,4-(chloromethyl)-3-fluoro- (8CI);

Chemical Property of 2-Fluoro-4-methoxybenzyl chloride

Chemical Property:

• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1.499
• Boiling Point: 215.4°Cat760mmHg
• Flash Point: 84.1°C
• PSA: 9.23000
• Density: 1.201g/cm³
• LogP: 2.57310

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-4-methoxybenzylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-4-methoxybenzyl chloride

There total 6 articles about 2-Fluoro-4-methoxybenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-fluoro-4-methoxyphenyl)methanol (405-09-4) → 1-(chloromethyl)-2-fluoro-4-methoxybenzene (331-63-5)

Guidance literature:

With pyridine; thionyl chloride; In diethyl ether; at 25 ℃; Cooling with ice; Schlenk technique;

DOI:10.1055/s-0039-1690111

Reference yield:

2-fluoro-4-methoxy-benzaldehyde (331-64-6) → 1-(chloromethyl)-2-fluoro-4-methoxybenzene (331-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: thionyl chloride / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

Reference yield:

1-fluoro-3-methoxybenzene (456-49-5) → 1-(chloromethyl)-2-fluoro-4-methoxybenzene (331-63-5)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / 1,2-dichloro-ethane / 2 h / Ambient temperature

2: 1.) Br₂, aq. NaOH / 1.) 10 deg C, 2.) dioxane, RT, 1 h

3: LiAlH₄ / diethyl ether / 1 h / Heating

4: HCl gas / benzene / 4 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; bromine; In diethyl ether; 1,2-dichloro-ethane; benzene;

DOI:10.1021/jm00171a031

upstream raw materials:

2-Fluor-4-methoxybenzoesaurechlorid

(2-fluoro-4-methoxyphenyl)methanol

1-fluoro-3-methoxybenzene

2-fluoro-4-methoxy-benzoic acid

Downstream raw materials:

acetylamino-(2-fluoro-4-methoxy-benzyl)-malonic acid diethyl ester

2-Fluoro₄-methoxy-benzenemethanethiol

Refernces

• 1、 Idzik, Tomasz J.,Borzyszkowska-Ledwig, Aleksandra,Struk, ?ukasz,So?nicki, Jacek G.. "Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine". supporting information. p. 9667 - 9671. Retrieved 2019/11/29.
• 2、 -. "7-amino-2-alkylthiopteridin-4-yl-amines for the treatment of chemokine-related diseases". Page/Page column 7. . Retrieved 2008/06/13.