456-49-5

Basic information

• Product Name: 3-Fluoroanisole
• Synonyms: M-FLUORO METHOXYBENZENE;M-FLUOROANISOLE;1-Fluoro-3-methoxybenzene;1-fluoro-3-methoxy-benzene;Benzene, 1-fluoro-3-methoxy-;3-Fluoroanisole,99%;3-Fluoroanisole 99%;m-Fluorophenyl methyl ether
• CAS NO: 456-49-5
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• EINECS: 207-267-4
• Product Categories: Other fluorin-contained compounds;AnisoleSeries;Fluorobenzene;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 456-49-5.mol
• Article Data: 47

Chemical Properties

• Melting Point: -35°C
• Boiling Point: 158 °C743 mm Hg(lit.)
• Flash Point: 111 °F
• Appearance: clear colorless to straw yellow liquid
• Density: 1.104 g/mL at 25 °C(lit.)
• Vapor Pressure: 38.3mmHg at 25°C
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: Flammables area
• Solubility: Chloroform, Methanol
• BRN: 1858895
• CAS DataBase Reference: 3-Fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoroanisole(456-49-5)
• EPA Substance Registry System: 3-Fluoroanisole(456-49-5)

Safety Data

• Hazard Codes: F
• Statements: 10
• Safety Statements: 16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 456-49-5(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to straw yellow liquid

Uses

Different sources of media describe the Uses of 456-49-5 differently. You can refer to the following data:
1. 3-Fluoroanisole is used in the preparation of tertiary benzylic nitriles.
2. 3-Fluoroanisole was used in the synthesis of 4-fluoro-5,6-dihydroxytryptamine. It was also used in the synthesis of 3-fluoro- and 5-fluoronoradrenaline.

InChI:InChI=1/C7H5F3O/c8-7(9,10)11-6-4-2-1-3-5-6/h1-5H

Upstream product

• 536-90-3 m-Anisidine 
• 77153-62-9 1-(3-Methoxyphenyl)-3,3-(1,5-pentanediyl)triazene 
• 100-66-3 methoxybenzene 
• 67-56-1 methanol 
• 372-18-9 1,3-Difluorobenzene 
• 76-05-1 trifluoroacetic acid 
• 372-20-3 3-fluorophenol 
• 458-50-4 1-bromo-2-fluoro-4-methoxybenzene 
• 162101-31-7 (2-fluoro-4-methoxyphenyl)boronic acid 
• 150-19-6 O-methylresorcine 
• 115991-13-4 bis(4-methoxyphenyl)iodonium fluoride 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 2113-56-6 3-methoxybiphenyl 
• 151-10-0 1,3-Dimethoxybenzene 
• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 
• 40586-05-8 7-(3-methoxyphenyl)heptan-1-ol 
• 1527-89-5 3-methoxybenzonitrile 
• 94610-82-9 2-fluoro-4-methoxyphenyl nitrile 
• 38474-02-1 1-(Ethylthio)-3-methoxybenzene 
• 394-18-3 1-fluoro-5-methoxy-2,4-dinitrobenzene 
• 17653-93-9 2-(3'-Methoxyphenyl)-2-methylpropionitrile 
• 21144-16-1 3-benzyloxyanisole 
• 192443-25-7 3-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene 
• 192436-87-6 (4-bromophenyl)(4-methoxy-2-methylsulfanylphenyl)methanone 
• 423161-73-3 3-(4-bromo-phenyl)-benzo[b]thiophen-6-ol 
• 192437-40-4 (4-bromophenyl)(4-hydroxy-2-methylsulfanylphenyl)methanone 

Relevant articles and documents

A Convenient and Stable Heterogeneous Nickel Catalyst for Hydrodehalogenation of Aryl Halides Using Molecular Hydrogen

Hydrodehalogenation is an effective strategy for transforming persistent and potentially toxic organohalides into their more benign congeners. Common methods utilize Pd/C or Raney-nickel as catalysts, which are either expensive or have safety concerns. In this study, a nickel-based catalyst supported on titania (Ni-phen@TiO2-800) is used as a safe alternative to pyrophoric Raney-nickel. The catalyst is prepared in a straightforward fashion by deposition of nickel(II)/1,10-phenanthroline on titania, followed by pyrolysis. The catalytic material, which was characterized by SEM, TEM, XRD, and XPS, consists of nickel nanoparticles covered with N-doped carbon layers. By using design of experiments (DoE), this nanostructured catalyst is found to be proficient for the facile and selective hydrodehalogenation of a diverse range of substrates bearing C?I, C?Br, or C?Cl bonds (>30 examples). The practicality of this catalyst system is demonstrated by the dehalogenation of environmentally hazardous and polyhalogenated substrates atrazine, tetrabromobisphenol A, tetrachlorobenzene, and a polybrominated diphenyl ether (PBDE).

Efficient synthesis method of meta-fluoranisole (by machine translation)

The method is characterized by comprising the following steps: taking m-chloronitrobenzene as a raw material, carrying out high-temperature chlorination reaction, nitration reaction and fluorination reaction to obtain 2,4 - 2,4 -difluorobenzene and carrying out a methoxylation reaction with m-difluorobenzene as a raw material and carrying out methoxylation reaction to obtain m-fluorobenzyl ether; and the hydrogenation catalyst is a porous alumina loaded NiO-Co222O3-MoOO3 composite catalyst. The method disclosed by the invention is simple in process and high in product yield. (by machine translation)

Hypervalent Iodine(III)-Catalyzed Balz–Schiemann Fluorination under Mild Conditions

An unprecedented hypervalent iodine(III) catalyzed Balz–Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25–60 °C), and features a wide substrate scope and good functional-group compatibility.