4-Amino-2-methylpyridine

Base Information

• Chemical Name: 4-Amino-2-methylpyridine
• CAS No.: 18437-58-6
• Molecular Formula: C6H8N2
• Molecular Weight: 108.143
• Hs Code.: 29333990
• European Community (EC) Number: 625-782-6
• DSSTox Substance ID: DTXSID90902504
• Nikkaji Number: J82.750I
• Mol file: 18437-58-6.mol

Synonyms:4-Amino-2-methylpyridine;18437-58-6;4-Amino-2-picoline;2-methylpyridin-4-amine;2-methyl-4-aminopyridine;2-methyl-4-pyridinamine;4-pyridinamine, 2-methyl-;2-Methyl-pyridin-4-ylamine;MFCD00186509;4-amino-picoline;4-amino-methylpyridine;2-methylpyridin-4-amin;NoName_3009;6-methylpyridin-4-amine;2-methylpyridine-4-amine;2-methylpyridin-4-ylamine;4-amino-2-methyl-pyridine;SCHEMBL266271;DTXSID90902504;4-Amino-2-methylpyridine, 97%;HMS1716O22;BCP22105;CS-D0974;CL0056;STK695662;AKOS000271091;AC-3013;PS-9288;SB10589;SY003568;AM20050905;FT-0637695;EN300-17881;Q-101508

Chemical Property of 4-Amino-2-methylpyridine

Chemical Property:

• Appearance/Colour: light yellow cryst
• Melting Point: 93-97 °C
• Boiling Point: 247.4 °C at 760 mmHg
• PKA: 9?+-.0.30(Predicted)
• Flash Point: 126.9 °C
• PSA: 38.91000
• Density: 1.068 g/cm³
• LogP: 1.55340
• Storage Temp.: Refrigerator
• Solubility.: Soluble in methanol.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 108.068748264
• Heavy Atom Count: 8
• Complexity: 72.9

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,T,Xi
• Hazard Codes: Xn,T,Xi
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-36/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1)N
• Uses: 4-Amino-2-methylpyridine is used to prepare 2-methyl-pyridin-4-ol; nitrate at 20°C.

Technology Process of 4-Amino-2-methylpyridine

There total 14 articles about 4-Amino-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-4-nitro-pyridine (13508-96-8) → 3-methyl-4-pyridinamine (18437-58-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h;

DOI:10.1055/s-0029-1218002

Reference yield: 99.0%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6)

Guidance literature:

With iron; acetic acid; at 70 ℃; for 3h;

Reference yield: 86.5%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-bis-(2,2'-dimethylpyridine) (100421-65-6)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Further byproducts given. Yields of byproduct given;

upstream raw materials:

2-methyl-isonicotinic acid amide

2-methyl-4-nitropyridine N-oxide

2-methyl-1-oxy-[4]pyridylamine; hydrochloride

4-amino-2-methylpyridine N-oxide

Downstream raw materials:

1-(2-Chloro-6-methyl-phenyl)-3-(2-methyl-pyridin-4-yl)-urea

4-acetylamino-2-methylpyridine

4-Hydroxy-N-(3-methylpyridin-4-yl)-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamide

4-amino-5-bromo-2-methylpyridine

Refernces

• 1、 -. "2-methyl-4-bromopyridine preparation method". Paragraph 0015; 0018; 0020; 0022; 0024; 0026; 0028. . Retrieved 2020/02/06.
• 2、 -. "AN IMPROVED PROCESS FOR PRODUCING AMINOPYRIDINES". Page/Page column 10. . Retrieved 2012/07/28.