2-Bromo-6-fluoroanisole

Base Information

• Chemical Name: 2-Bromo-6-fluoroanisole
• CAS No.: 845829-94-9
• Molecular Formula: C7H6BrFO
• Molecular Weight: 205.026
• Hs Code.: 2909309090
• Mol file: 845829-94-9.mol

Synonyms:1-Bromo-3-fluoro-2-methoxybenzene;2-Bromo-6-fluorophenyl methyl ether;3-Bromo-1-fluoro-2-methoxybenzene;

Chemical Property of 2-Bromo-6-fluoroanisole

Chemical Property:

• Vapor Pressure: 0.306mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 208.587 °C at 760 mmHg
• Flash Point: 94.379 °C
• PSA: 9.23000
• Density: 1.532 g/cm³
• LogP: 2.59680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-fluoroanisole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-6-fluoroanisole is a reactant in the preparation of quinazolines as a c-jun N-terminal kinase (JNK) inhibitor with good brain penetration.

Technology Process of 2-Bromo-6-fluoroanisole

There total 8 articles about 2-Bromo-6-fluoroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-6-fluorophenol (2040-89-3) + methyl iodide (74-88-4) → 1-bromo-3-fluoro-2-methoxybenzene (845829-94-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2014.10.073

Reference yield:

3-fluoro-2-methoxyaniline (437-83-2) → 1-bromo-3-fluoro-2-methoxybenzene (845829-94-9)

Guidance literature:

3-fluoro-2-methoxyaniline; With hydrogen bromide; sodium nitrite; at 0 - 5 ℃;

With hydrogen bromide; copper(I) bromide; at 60 ℃;

DOI:10.1021/jm060844e

Reference yield:

C7H7BrFNO (875664-44-1) → 1-bromo-3-fluoro-2-methoxybenzene (845829-94-9)

Guidance literature:

With isopentyl nitrite; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Temperature;

upstream raw materials:

3-fluoro-2-methoxyaniline

2-fluoro-6-nitrophenol

1-fluoro-2-methoxy-3-nitrobenzene

2-fluorophenol

Downstream raw materials:

4-bromo-2-fluoro-3-methoxybenzoic acid

4-bromo-2-fluoro-3-methoxybenzoic acid

4-bromo-2-fluoro-3-methoxybenzonitrile

Refernces

• 1、 -. "COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND F1BROTIC DISEASE". Paragraph 00705. . Retrieved 2020/07/14.
• 2、 Zhang, Heng,Xu, Xiangqing,Chen, Yin,Qiu, Yinli,Liu, Xin,Liu, Bi-Feng,Zhang, Guisen. "Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression". . p. 524 - 539. Retrieved 2014/12/11.