imidazole

Base Information

• Chemical Name: imidazole
• CAS No.: 1600562-76-2
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• Mol file: 1600562-76-2.mol

Synonyms:imidazole

Chemical Property of imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of imidazole

There total 3 articles about imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1H-imidazol-1-yl)benzaldehyde (151055-86-6) + diethyl malonate (105-53-3) → imidazole (1600562-76-2)

Guidance literature:

With piperidine; benzoic acid; In benzene; Reflux; Dean-Stark;

DOI:10.1016/j.tet.2014.02.031

Reference yield:

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) → imidazole (1600562-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; L-proline / dimethyl sulfoxide / 130 °C / Inert atmosphere

2: hydrogenchloride / water / 20 °C

3: piperidine; benzoic acid / benzene / Reflux; Dean-Stark

With piperidine; hydrogenchloride; copper(l) iodide; benzoic acid; L-proline; In water; dimethyl sulfoxide; benzene;

DOI:10.1016/j.tet.2014.02.031

Reference yield:

2-<2-(1H-imidazol-1-yl)phenyl>-1,3-dioxolane (151055-84-4) → imidazole (1600562-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 20 °C

2: piperidine; benzoic acid / benzene / Reflux; Dean-Stark

With piperidine; hydrogenchloride; benzoic acid; In water; benzene;

DOI:10.1016/j.tet.2014.02.031

upstream raw materials:

2-(2-bromophenyl)-1,3-dioxolan

2-<2-(1H-imidazol-1-yl)phenyl>-1,3-dioxolane

2-(1H-imidazol-1-yl)benzaldehyde

diethyl malonate

Downstream raw materials:

1-(2-(3-ethoxy-2-(ethoxycarbonyl)-3-oxoprop-1-en-1-yl)phenyl)-3-methyl-1H-imidazol-3-ium iodide

Refernces