2-(2-BROMOPHENYL)-1,3-DIOXOLANE

Base Information

• Chemical Name: 2-(2-BROMOPHENYL)-1,3-DIOXOLANE
• CAS No.: 34824-58-3
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Hs Code.: 29329900
• Mol file: 34824-58-3.mol

Synonyms:o-Bromobenzaldehyde ethylene glycol acetal;o-Bromobenzaldehyde ethylene acetal;2-(o-Bromophenyl)-1,3-dioxolane;2-(1,3-Dioxolan-2-yl)bromobenzene;2-(1,3-Dioxolan-2-yl)-1-bromobenzene;

Chemical Property of 2-(2-BROMOPHENYL)-1,3-DIOXOLANE

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 0.0103mmHg at 25°C
• Refractive Index: n20/D 1.569(lit.)
• Boiling Point: 272.1 °C at 760 mmHg
• Flash Point: 120.8 °C
• PSA: 18.46000
• Density: 1.515 g/cm³
• LogP: 2.49450
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Difficult to mix in water.

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Bromophenyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of 2-(2-BROMOPHENYL)-1,3-DIOXOLANE

There total 10 articles about 2-(2-BROMOPHENYL)-1,3-DIOXOLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethylene glycol (107-21-1) + ortho-bromobenzaldehyde (6630-33-7) → 2-(2-bromophenyl)-1,3-dioxolan (34824-58-3)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 4h; Heating / reflux;

Reference yield: 94.0%

ortho-bromobenzaldehyde (6630-33-7) → 2-(2-bromophenyl)-1,3-dioxolan (34824-58-3)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; toluene;

Reference yield: 93.0%

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) + ortho-bromobenzaldehyde (6630-33-7) → 2-(2-bromophenyl)-1,3-dioxolan (34824-58-3)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; at 20 ℃; for 1.5h;

DOI:10.1055/s-0030-1258148

upstream raw materials:

ethylene glycol

ortho-bromobenzaldehyde

2-chloro-ethanol

2-methylphenyl bromide

Downstream raw materials:

Ethyl 2-<2-(1,3-dioxolan-2-yl)phenylacetate>

o-allylbenzaldehyde

2-(2-propenyl)benzaldehyde ethylene glycol acetal

2,2'-<1,1'-biphenyl>-2,2'-diylbis(1,3-dioxolane)

Refernces

• 1、 Mondal, Atanu,Satpathi, Bishnupada,Ramasastry. "Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α-Substituted Enones". supporting information. p. 256 - 261. Retrieved 2022/01/04.
• 2、 Xu, Guangyang,Wang, Zhen,Shao, Ying,Sun, Jiangtao. "Copper-Catalyzed Tandem Cross-Coupling and Alkynylogous Aldol Reaction: Access to Chiral Exocyclic α-Allenols". supporting information. p. 5175 - 5179. Retrieved 2021/07/19.