5-BROMO-2-METHOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 5-BROMO-2-METHOXYPHENYLACETIC ACID
• CAS No.: 7017-48-3
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 7017-48-3.mol

Synonyms:Aceticacid, (5-bromo-2-methoxyphenyl)- (7CI,8CI);5-Bromo-2-methoxyphenylacetic acid;[5-Bromo-2-(methyloxy)phenyl]acetic acid;2-(5-bromo-2-methoxyphenyl)acetic acid;

Chemical Property of 5-BROMO-2-METHOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 1.33E-05mmHg at 25°C
• Melting Point: 132-134 °C
• Refractive Index: 1.572
• Boiling Point: 353.3 °C at 760 mmHg
• PKA: 3.97±0.10(Predicted)
• Flash Point: 167.5 °C
• PSA: 46.53000
• Density: 1.56 g/cm³
• LogP: 2.08480
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-methoxyphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHOXYPHENYLACETIC ACID

There total 6 articles about 5-BROMO-2-METHOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-methoxyphenylacetic acid (93-25-4) → 2-(5-bromo-2-methoxyphenyl)acetic acid (7017-48-3)

Guidance literature:

With mercury(II) diacetate; bromine; In acetic acid; at 20 ℃; for 1h;

Reference yield:

5-bromo-2-methoxyphenylacetic acid ethyl ester (863562-62-3) → 2-(5-bromo-2-methoxyphenyl)acetic acid (7017-48-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.05.116

Reference yield:

1-(cyanomethyl)-2-methoxy-6-bromobenzene (7062-40-0) → 2-(5-bromo-2-methoxyphenyl)acetic acid (7017-48-3)

Guidance literature:

With potassium hydroxide; at 100 - 110 ℃;

upstream raw materials:

1-(cyanomethyl)-2-methoxy-6-bromobenzene

2-methoxyphenylacetic acid

5-bromo-2-methoxyphenylacetic acid ethyl ester

5-bromo-2-methoxy-benzyl alcohol

Downstream raw materials:

2-(5-bromo-2-methoxyphenyl)-1-ethanol

methyl 2-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

2-(5-bromo-2-methoxyphenyl)ethanyl tetrahydropyranyl ether

Refernces

• 1、 Brown, Allan G.,Crimmin, Michael J.,Edwards, Peter D.. "Application of the Suzuki Biphenyl Synthesis to the Natural Products Biphenomycin and Vancomycin". . p. 123 - 130. Retrieved 2007/10/02.