7062-40-0

Basic information

• Product Name: 5-BROMO-2-METHOXYPHENYLACETONITRILE
• Synonyms: 5-BROMO-2-METHOXYPHENYLACETONITRILE;2-(5-broMo-2-Methoxyphenyl)acetonitrile;Benzeneacetonitrile, 5-broMo-2-Methoxy-;5-BroMo-2-Methoxybenzyl cyanide;5-Bromo-2-methoxybenzyl cyanide, 4-Bromo-2-(cyanomethyl)anisole
• CAS NO: 7062-40-0
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Product Categories: Aromatic Nitriles
• Mol File: 7062-40-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 61-63°C
• Boiling Point: 580.8°C at 760 mmHg
• Flash Point: 305.1°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 1.75E-13mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BROMO-2-METHOXYPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHOXYPHENYLACETONITRILE(7062-40-0)
• EPA Substance Registry System: 5-BROMO-2-METHOXYPHENYLACETONITRILE(7062-40-0)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 7062-40-0(Hazardous Substances Data)

Usage

Uses

2-(5-Bromo-2-methoxyphenyl)acetonitrile is a useful intermediate used in the synthesis of 5-bromo-2-methoxyphenylacetonitrile and some of its derivatives.

InChI:InChI=1/C21H22N4O2S/c1-4-8-28-20-24-18-17(19(27)25-20)15(12-6-5-7-22-11-12)16-13(23-18)9-21(2,3)10-14(16)26/h4-7,11,15H,1,8-10H2,2-3H3,(H2,23,24,25,27)

Upstream product

• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 151-50-8 potassium cyanide 

Downstream Products

• 73775-47-0 2-(2-Methoxy-5-bromobenzyl)-2-imidazoline hydrochloride 
• 73775-42-5 2-(5-Bromo-2-methoxy-phenyl)-acetamidine; hydrochloride 
• 163813-58-9 N-<2-(2-methoxy-5-bromophenyl)ethyl>acetamide 
• 149488-99-3 2-(2-methoxy-5-bromophenyl)-1-aminoethane 
• 73775-39-0 2-(5-Bromo-2-methoxy-phenyl)-acetimidic acid ethyl ester; hydrochloride 
• 7017-48-3 2-(5-bromo-2-methoxyphenyl)acetic acid 
• 863562-62-3 5-bromo-2-methoxyphenylacetic acid ethyl ester 
• 294860-58-5 methyl 2-(5-bromo-2-methoxyphenyl)acetate 

Relevant articles and documents

Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes

A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reacti

TRIAZOLONE COMPOUNDS AND USES THEREOF

The invention disclosed herein is directed to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula (I), or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections. The invention disclosed herein is also directed to a methods of preventing the onset of and/or recurrence of acute and chronic myeloid leukemia, as well as other cancers, comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist.