4,4-(ETHYLENEDIOXY)-1-TERT-BUTOXYCARBONYLPIPERIDINE

Base Information

• Chemical Name: 4,4-(ETHYLENEDIOXY)-1-TERT-BUTOXYCARBONYLPIPERIDINE
• CAS No.: 123387-51-9
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.303
• Hs Code.: 2934999090
• Mol file: 123387-51-9.mol

Synonyms:1-tert-Butoxycarbonyl-4-piperidoneethylene ketal;4,4-(Ethylenedioxy)-1-tert-butoxycarbonylpiperidine;8-(tert-Butoxycarbonyl)-1,4-dioxa-8-azaspiro[4.5]decane;N-Boc-1,4-dioxa-8-aza-spiro[4.5]decane;

Chemical Property of 4,4-(ETHYLENEDIOXY)-1-TERT-BUTOXYCARBONYLPIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 330.826 °C at 760 mmHg
• Flash Point: 153.878 °C
• PSA: 48.00000
• Density: 1.145 g/cm³
• LogP: 1.69830
• Storage Temp.: 2-8°C
• Solubility.: Methanol, Tetrahydrofuran

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic Acid 1,1-Dimethylethyl Ester (cas# 123387-51-9) is a compound useful in organic synthesis.

Technology Process of 4,4-(ETHYLENEDIOXY)-1-TERT-BUTOXYCARBONYLPIPERIDINE

There total 6 articles about 4,4-(ETHYLENEDIOXY)-1-TERT-BUTOXYCARBONYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 4,4-ethylenedioxy-piperidine (177-11-7) → tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate (123387-51-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; for 3h;

Reference yield: 90.0%

carbon monoxide (201230-82-2) + 4,4-ethylenedioxy-piperidine (177-11-7) + tert-butyl alcohol (75-65-0) → tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate (123387-51-9)

Guidance literature:

With gold(III) chloride; copper(l) iodide; at 20 ℃; for 24h; under 750.075 - 3000.3 Torr;

DOI:10.1002/cssc.202102400

Reference yield: 87.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + ethylene glycol (107-21-1) → tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate (123387-51-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 8h; Reflux;

DOI:10.1007/s10600-010-9581-x

upstream raw materials:

di-tert-butyl dicarbonate

4,4-ethylenedioxy-piperidine

N-tert-butyloxycarbonylpiperidin-4-one

ethylene glycol

Downstream raw materials:

4,4-ethylenedioxy-piperidine

Refernces

• 1、 Cao, Yanwei,Huang, Yang,He, Lin. "Sustainable Route Toward N-Boc Amines: AuCl3/CuI-Catalyzed N-tert-butyloxycarbonylation of Amines at Room Temperature". . . Retrieved 2021/12/22.
• 2、 Vu, Van Ha,Louafi, Fadila,Girard, Nicolas,Marion, Ronan,Roisnel, Thierry,Dorcet, Vincent,Hurvois, Jean-Pierre. "Electrochemical access to 8-(1-phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5] decane-7-carbonitrile. Application to the asymmetric syntheses of (+)-myrtine and alkaloid (+)-241D". . p. 3358 - 3373. Retrieved 2014/05/06.