3-CYCLOHEXYL-PROPYLAMINE

Base Information

• Chemical Name: 3-CYCLOHEXYL-PROPYLAMINE
• CAS No.: 4361-44-8
• Molecular Formula: C9H19N
• Molecular Weight: 141.257
• Hs Code.: 2921300090
• Mol file: 4361-44-8.mol

Synonyms:3-Cyclohexyl-propylamine;

Chemical Property of 3-CYCLOHEXYL-PROPYLAMINE

Chemical Property:

• Boiling Point: 191.846 °C at 760 mmHg
• Flash Point: 64.68 °C
• PSA: 26.02000
• Density: 0.86 g/cm³
• LogP: 3.00590
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

3-Cyclohexylpropan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CYCLOHEXYL-PROPYLAMINE

There total 12 articles about 3-CYCLOHEXYL-PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-[3-cyclohexylprop-1-yl]phthalimide (144290-77-7) → 3-cyclohexylpropan-1-amine (4361-44-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.00555556h;

DOI:10.1016/0223-5234(92)90145-Q

Reference yield: 40.0%

→ 2-naphthalen-1-yl-ethylamine (4735-50-6) + 3-cyclohexylpropan-1-amine (4361-44-8)

Guidance literature:

Reference yield:

3-cyclohexylpropanamide (4361-29-9) → 3-cyclohexylpropan-1-amine (4361-44-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b00553

upstream raw materials:

3-cyclohexylpropionitrile

N-[3-cyclohexylprop-1-yl]phthalimide

3-cyclohexylpropyl chloride

3-cyclohexylpropan-1-ol

Downstream raw materials:

(2R,3R,4S,5R)-2-[6-Amino-2-(3-cyclohexyl-propylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol

1-(3-Cyclohexyl-propylamino)-3-phenoxy-propan-2-ol; hydrochloride

[(S)-5-tert-Butoxycarbonylamino-5-(3-cyclohexyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester

[(S)-5-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-5-(3-cyclohexyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester

Refernces

• 1、 Hu, Qu-Ping,Cheng, Jing,Wang, Ying,Shi, Jie,Wang, Bi-Qin,Hu, Ping,Zhao, Ke-Qing,Pan, Fei. "Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes". . p. 4457 - 4462. Retrieved 2021/05/26.
• 2、 Zhang, Hongwei,Zhou, Yulu,Tian, Peiyuan,Jiang, Cuiyu. "Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated Csp3-H Bonds". . . Retrieved 2019/03/19.