1,2-bis(3,5-difluorophenyl)acetylene

Base Information

• Chemical Name: 1,2-bis(3,5-difluorophenyl)acetylene
• CAS No.: 1314234-16-6
• Molecular Formula: C₁₄H₆F₄
• Molecular Weight: 250.195
• Mol file: 1314234-16-6.mol

Synonyms:1,2-bis(3,5-difluorophenyl)acetylene

Chemical Property of 1,2-bis(3,5-difluorophenyl)acetylene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1,2-bis(3,5-difluorophenyl)acetylene

There total 1 articles about 1,2-bis(3,5-difluorophenyl)acetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,3-difluoro-5-iodobenzene (2265-91-0) + trimethylsilylacetylene (1066-54-2) → 1,2-bis(3,5-difluorophenyl)acetylene (1314234-16-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 60 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c2cc33892k

Reference yield: 89.0%

1,2-bis(3,5-difluorophenyl)acetylene (1314234-16-6) → 1,2-bis(4-fluorophenyl)ethane-1,2-dione (579-39-5)

Guidance literature:

With iodine; dimethyl sulfoxide; at 155 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c2cc33892k

Reference yield: 42.0%

1,2-bis(3,5-difluorophenyl)acetylene (1314234-16-6) → 6,8-difluoro-1,2,3-tris(3,5-difluorophenyl)naphthalene (1314234-24-6) + (8β,8aα)-5,7-difluoro-1,2,3,8,8a-pentakis(3,5-difluorophenyl)-8,8a-dihydrocyclopenta[a]indene

Guidance literature:

With palladium diacetate; copper(II) acetate monohydrate; potassium carbonate; p-benzoquinone; tricyclohexylphosphine; In water; acetonitrile; at 110 ℃; for 36h; Inert atmosphere;

DOI:10.1002/chem.201100437

upstream raw materials:

1,3-difluoro-5-iodobenzene

trimethylsilylacetylene

Downstream raw materials:

6,8-difluoro-1,2,3-tris(3,5-difluorophenyl)naphthalene

1,2-bis(4-fluorophenyl)ethane-1,2-dione

Refernces