2-HYDROXYDECANOIC ACID

Base Information

• Chemical Name: 2-HYDROXYDECANOIC ACID
• CAS No.: 37639-46-6
• Molecular Formula: C₁₀H₂₀O₃
• Molecular Weight: 188.267
• Mol file: 37639-46-6.mol

Synonyms:(+/-)-2-HYDROXYDECANOIC ACID;2-HYDROXYDECANOIC ACID;(+/-)-2-HYDROXYDODECANOIC ACID;2-HYDROXY C10:0 ACID;ALPHA-HYDROXY DECANOIC ACID;ALPHA-HYDROXYCAPRIC ACID;DL-2-HYDROXYDECANOIC ACID;HYDROXYCAPRIC ACID

Chemical Property of 2-HYDROXYDECANOIC ACID

Chemical Property:

• Vapor Pressure: 2.9E-05mmHg at 25°C
• Refractive Index: 1.464
• Boiling Point: 318.9 °C at 760 mmHg
• Flash Point: 160.9 °C
• PSA: 57.53000
• Density: 1.011 g/cm³
• LogP: 2.18250
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXYDECANOIC ACID

There total 49 articles about 2-HYDROXYDECANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-Acetoxy-decanoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester → (S)-2-Hydroxydecanoic acid (70267-29-7,37639-46-6) + (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide (99295-72-4)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 20h;

DOI:10.1002/hlca.19850680127

Reference yield: 95.0%

1-decanoic acid (334-48-5) → DL-2-hydroxydecanoic acid (5393-81-7,37639-46-6)

Guidance literature:

With P_450CLA; dihydrogen peroxide; In aq. phosphate buffer; ethanol; at 20 ℃; for 12.5h; pH=7.25; regioselective reaction; Catalytic behavior; Enzymatic reaction;

DOI:10.1002/adsc.201801377

Reference yield: 88.0%

S-methyl 2-hydroxydecanethioate (124838-42-2) → DL-2-hydroxydecanoic acid (5393-81-7,37639-46-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; water; for 1h; Heating;

DOI:10.1246/bcsj.62.2013

upstream raw materials:

(S)-2-acetoxybutanedioic acid 1-ethyl ester

Octanoic acid

L-2-aminodecanoic acid

2-Hydroxycaprinsaeure-methylester

Downstream raw materials:

2-Hydroxycaprinsaeure-methylester

N-phenyl-2-hydroxy-decanamide

(R)-2-hydroxydecanoic acid

2-oxodecanoic acid

Refernces

• 1、 Armbruster, Julia,Steinmassl, Mathilde,Müller Bogotá, Christina A.,Berg, Gabriele,Nidetzky, Bernd,Dennig, Alexander. "P450Jα: A New, Robust and α-Selective Fatty Acid Hydroxylase Displaying Unexpected 1-Alkene Formation". . p. 15910 - 15921. Retrieved 2020/10/29.
• 2、 Dennig, Alexander,Blaschke, Fabio,Gandomkar, Somayyeh,Tassano, Erika,Nidetzky, Bernd. "Preparative Asymmetric Synthesis of Canonical and Non-canonical a-amino Acids through Formal Enantioselective Biocatalytic Amination of Carboxylic Acids". supporting information. p. 1348 - 1358. Retrieved 2019/10/28.