3,3,3-TRIFLUORO-2-(TRIFLUOROMETHYL)PROPIONIC ACID

Base Information

• Chemical Name: 3,3,3-TRIFLUORO-2-(TRIFLUOROMETHYL)PROPIONIC ACID
• CAS No.: 564-10-3
• Molecular Formula: C4H2F6O2
• Molecular Weight: 196.049
• Hs Code.: 29159000
• Mol file: 564-10-3.mol

Synonyms:Propionicacid, 3,3,3-trifluoro-2-(trifluoromethyl)- (6CI,7CI,8CI);2-Trifluoromethyl-3,3,3-trifluoropropionic acid;3,3,3-Trifluoro-2-(trifluoromethyl)propanoic acid;3,3,3-Trifluoro-2-(trifluoromethyl)propionic acid;Hexafluoroisobutyric acid;Monohydrohexafluoroisobutyric acid;a-Hydroperfluoroisobutyric acid;3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid;propanoic acid, 3,3,3-trifluoro-2-(trifluoromethyl)-;2-(Trifluoromethyl)-3,3,3-trifluoropropionic acid;propionic acid, 2-(trifluoromethyl)-3,3,3-trifluoro-;

Chemical Property of 3,3,3-TRIFLUORO-2-(TRIFLUOROMETHYL)PROPIONIC ACID

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 13.6mmHg at 25°C
• Melting Point: 50-53 °C(lit.)
• Refractive Index: 1.301
• Boiling Point: 113.6 °C at 760 mmHg
• Flash Point: 22.5 °C
• PSA: 37.30000
• Density: 1.602 g/cm³
• LogP: 1.81180

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Trifluoromethyl)-3,3,3-trifluoropropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C；Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3,3-TRIFLUORO-2-(TRIFLUOROMETHYL)PROPIONIC ACID

There total 11 articles about 3,3,3-TRIFLUORO-2-(TRIFLUOROMETHYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,3,3-trifluoro-2-trifluoromethylpropionyl chloride (382-19-4) → 3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid (564-10-3)

Guidance literature:

With water; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.jfluchem.2012.03.013

Reference yield: 79.0%

α-cyanohexafluoroisobutenyl α-hydrohexafluoroisobutyrate (74047-17-9) → 3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid (564-10-3)

Guidance literature:

With water; for 480h;

DOI:10.1007/BF00961761

Reference yield: 70.0%

perfluoroisobutylene (382-21-8) → 3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid (564-10-3)

Guidance literature:

With water; In acetone; at 20 ℃; for 72h;

DOI:10.1016/j.ejmech.2009.08.007

upstream raw materials:

α-hydrohexafluoroisobutyric acid ethyl ester

perfluoroisobutylene

3,3,3-trifluoro-2-trifluoromethyl-propionyl fluoride

4-hexafluoroisopropylidene-1,3,2-dioxathietane 2,2-dioxide

Downstream raw materials:

3,3,3-trifluoro-2-trifluoromethylpropionyl chloride

1,1,1,3,3,3-hexafluoropropane

2-chloro-1,1,1,3,3,3-hexafluoropropane

benzyl 3,3,3-trifluoro-2-trifluoromethyl-propionate

Refernces

• 1、 Cheburkov,Yu.A.,Knunyants,I.L.. "-". . . Retrieved 1963.
• 2、 -. "Preparation method of 1, 1, 1, 3, 3, 3-hexafluoropropane". Paragraph 0035-0039. . Retrieved 2019/05/08.
• 3、 Luzina, Elena L.,Popov, Anatoliy V.. "Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds". . p. 41 - 48. Retrieved 2013/04/10.