382-21-8 Usage
Description
Perfluoroisobutylene (PFIB) is a schedule 2A substance under
the Chemical Weapons Convention, which means that while it
has significant ability to be used as a chemical weapon, it also
serves various other industrial uses.
Uses
Perfluoroisobutylene or perfluoroisobutene is a monomer used
in synthesis of Teflon and other polymeric materials. It is also
used in etching for semiconductor fabrication, and is potentially
used as a chemical warfare agent. The US Food and Drug
Administration’s CFR 21 Section 173.360 allows for use of
octafluorocyclobutane as a propellant and also allows for PFIB
at a level of <.01% as an impurity in formulation.
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 2698, 1953 DOI: 10.1021/ja01107a044
Safety Profile
A deadly poison by inhalation. Askin, eye, and mucous membrane irritant. Human acuteexposure causes marked irritation of conjunctivae, throat,and lungs. When heated to decompos
Environmental Fate
PFIB exists as a gas in the atmosphere, and is degraded by
reaction with hydroxyl radicals, with a reaction half-life
of ~5.7 days. PFIB is not susceptible to significant photolysis.
The Henry’s law constant of PFIB suggests volatization as
an important fate process. The half lives for volatization
calculated from a model lake and river were 5.6 days and
4.1 h, respectively, though a small portion will adsorb to
suspended solids and sediment. PFIB can also volatize
substantially from moist soils, and to a small degree from dry
soils.
Toxicity evaluation
PFIB is a strong electrophile that reacts with nucleophiles. The
toxicity of PFIB may be correlated with its susceptibility to
nucleophilic attack and the generation of reactive
intermediates.
Check Digit Verification of cas no
The CAS Registry Mumber 382-21-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 382-21:
(5*3)+(4*8)+(3*2)+(2*2)+(1*1)=58
58 % 10 = 8
So 382-21-8 is a valid CAS Registry Number.
InChI:InChI=1/C4F8/c5-2(6)1(3(7,8)9)4(10,11)12
382-21-8Relevant articles and documents
Gregory et al.
, p. 991 (1969)
Generation of Perfluoroisobutylene Reference Sample and Determination by Gas Chromatography with Electron Capture and Flame Ionization Detection
Marhevka, John S.,Johnson, Glenn D.,Hagen, Donald F.,Danielson, Richard D.
, p. 2607 - 2610 (1982)
-
IR Matrix Isolation Product Characterization from Low-Pressure Pyrolysis of CnF2n+1I (n = 1-4) and C6F5I
Butler, R.,Snelson, A.
, p. 345 - 350 (1980)
-
Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
Luzina, Elena L.,Popov, Anatoliy V.
, p. 82 - 88 (2015/06/25)
A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.
PYROLYSIS PROCESS
-
Page/Page column 4, (2008/06/13)
The present invention relates to the pyrolysis of hydrochlorofluorocarbons to form fluoromonomers such as tetrafluoroethylene, the pyrolysis being carried out in a reaction zone lined with nickel and mechanically supported by a jacket of other corrosion resistant metal, the nickel lining providing an improved yield of valuable reaction products.
