2-Fluoroacrylic acid

Base Information

• Chemical Name: 2-Fluoroacrylic acid
• CAS No.: 430-99-9
• Molecular Formula: C3H3FO2
• Molecular Weight: 90.054
• Hs Code.: 2916190090
• European Community (EC) Number: 692-468-3
• UNII: BEP1A791CI
• DSSTox Substance ID: DTXSID10902405
• Nikkaji Number: J799.524E
• Wikidata: Q27274622
• Mol file: 430-99-9.mol

Synonyms:2-Fluoroacrylic acid;430-99-9;2-fluoropropenoic acid;2-fluoroprop-2-enoic Acid;alpha-Fluoroacrylic acid;2-Propenoic acid, fluoro-;2-Propenoic acid, 2-fluoro-;UNII-BEP1A791CI;BEP1A791CI;74893-46-2;MFCD03424474;2-Fluoroacrylic acid, sodium salt;C3H3FO2;fluoroacrylic acid;alpha-fluoroacrylate;DTXSID10902405;TYCFGHUTYSLISP-UHFFFAOYSA-N;.ALPHA.-FLUOROACRYLIC ACID;BCP31987;ZCA89346;AKOS006230202;AM84938;CS-W005285;AS-57293;SY021247;FT-0676569;2-fluoroprop-2-enoic acid;EN300-104748;A826153;J-509509;Q27274622;2-Fluoroprop-2-enoic Acid

Chemical Property of 2-Fluoroacrylic acid

Chemical Property:

• Vapor Pressure: 0.397mmHg at 25°C
• Melting Point: 51.5 °C
• Refractive Index: 1.388
• Boiling Point: 181.3 °C at 760 mmHg
• PKA: pK1:2.55 (25°C)
• Flash Point: 63.5 °C
• PSA: 37.30000
• Density: 1.233 g/cm³
• LogP: 0.55420
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 90.01170750
• Heavy Atom Count: 6
• Complexity: 86.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoroacrylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=C(C(=O)O)F
• Uses: 2-Fluoroacrylic Acid is a monomeer used for the preparation of fluoropolymers . It is also used a s a reactant for the preparation of fluorolactams.

Technology Process of 2-Fluoroacrylic acid

There total 3 articles about 2-Fluoroacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

methanol (67-56-1) + 1-bromo-1-fluoroethylene (420-25-7) + carbon monoxide (201230-82-2) → 2-fluoroacrylic acid (430-99-9) + methyl 2-fluoroprop-2-enoate (2343-89-7)

Guidance literature:

With dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); triethylamine; at 100 ℃; for 13h; under 7500.75 Torr; Autoclave;

Reference yield: 39.0%

ethyl 2-fluoroacrylate (760-80-5) → 2-fluoroacrylic acid (430-99-9)

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield:

methanol (67-56-1) + 1-chloro-1-fluoroethane (2317-91-1) + carbon monoxide (201230-82-2) → 2-fluoroacrylic acid (430-99-9) + methyl 2-fluoroprop-2-enoate (2343-89-7)

Guidance literature:

With 1,4-bis(dicyclohexylphosphino)butane; palladium(II) acetylacetonate; triethylamine; at 85 ℃; for 26h; Temperature; Autoclave;

upstream raw materials:

ethyl 2-fluoroacrylate

methanol

1-bromo-1-fluoroethylene

carbon monoxide

Downstream raw materials:

4-Nitro-α-chlor-α-fluor-dihydrozimtsaeure

N-allyl-N-benzyl-2-fluoroacrylamide

N-benzyl-N-(but-3-enyl)-α-fluoroacrylamide

5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-(2-fluoroacryloyl)piperidin-3-yl]-1H-pyrazole-4-carboxamide

Refernces

• 1、 -. "PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS". Paragraph 0149; 0150. . Retrieved 2016/11/17.
• 2、 Tolman, Vladimir,Spronglova, Pavla. "SYNTHESIS OF 2-FLUOROPROPENOIC ACID DERIVATIVES". . p. 319 - 326. Retrieved 2007/10/02.