2343-89-7

Basic information

• Product Name: METHYL 2-FLUOROACRYLATE
• Synonyms: Methyl fluoroacrylate;2-Propenoic acid, 2-fluoro-, methyl ester;Methyl 2-fluoroprop-2-enoate;Methyl 2-fluoroacrylate, BHT stablized;2-FLUOROACRYLATE;METHYL 2-FLUOROACRYLATE;2-FLUOROPROPENOIC ACID METHYL ESTER;2-Fluoroacrylic acid methyl ester
• CAS NO: 2343-89-7
• Molecular Formula: C₄H₅FO₂
• Molecular Weight: 104.08
• Product Categories: Building Blocks/Intermediates;monomer
• Mol File: 2343-89-7.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 41°C
• Flash Point: 1.1 °C
• Appearance: /Liquid
• Density: 1,114 g/cm3
• Vapor Pressure: 103mmHg at 25°C
• Refractive Index: 1.39
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: METHYL 2-FLUOROACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-FLUOROACRYLATE(2343-89-7)
• EPA Substance Registry System: METHYL 2-FLUOROACRYLATE(2343-89-7)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36-24/25
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅱ
• Hazardous Substances Data: 2343-89-7(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

Methyl 2-fluoroacrylate is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis Reference(s)

Synthetic Communications, 11, p. 901, 1981 DOI: 10.1080/00397918108065745

InChI:InChI=1/C4H5FO2/c1-3(5)4(6)7-2/h1H2,2H3

Synthetic route

Methyl 2-Fluoro-3-(4-toluenesulfonyloxy)propanoate (85345-88-6) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With potassium phtalimide at -78 - 150℃; under 0.01 Torr;	97%

Methyl 3-chloro-2-fluoropropanoate (55900-27-1) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium phosphate In 1-methyl-pyrrolidin-2-one at 150℃; under 112.511 - 225.023 Torr;	95%
With dimethyl amine In diethyl ether; benzene

methanol (67-56-1) + 2-fluoroacrylic acid (430-99-9) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With thionyl chloride at 5 - 35℃; for 2h; Concentration; Reagent/catalyst;	93%

dimethyl 2-fluoro-2-chloromethylmalonate → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; under 225.023 Torr; for 4h;	92%

methanol (67-56-1) + 1-chloro-1-fluoroethane (2317-91-1) + carbon monoxide (201230-82-2) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With dichloro[ferrocene-1,1'-diylbis(diisopropylphosphine-P)]palladium(II); triethylamine at 100℃; under 5250.53 Torr; for 8h; Reagent/catalyst; Autoclave;	91.8%
With bis(tri-t-butylphosphine)palladium(0) at 100℃; for 18h; Reagent/catalyst; Time; Autoclave;	77.4%

methanol (67-56-1) + 1-bromo-1-fluoroethylene (420-25-7) + carbon monoxide (201230-82-2) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; lithium carbonate; triethylamine at 90℃; for 6h; Reagent/catalyst; Temperature; Autoclave;	90.7%
With dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II); triethylamine at 100℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Autoclave;	90.1%
With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; lithium carbonate at 90℃; under 7500.75 Torr; for 6h; Reagent/catalyst; Autoclave;	71.8 g

1-chloro-1-fluoro-2,2-dimethoxycyclopropane → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; methoxybenzene at 120 - 130℃; under 500 Torr; Reagent/catalyst; Temperature;	89.5%
With 2,6-di-tert-butyl-4-methyl-phenol at 145℃; under 360 Torr;	12.3 g

methyl 3-bromo-2-fluoro-2-chloropropanoate (2365-93-7) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 10H-phenothiazine; sulfuric acid; zinc In water at 82 - 86℃; for 0.333333h;	85%
With hydrogen sulfide; sodium N-nitroso-N-phenylhydroxylaminate; zinc In water at 100℃;	82%
With zinc	80%
With sulfuric acid; zinc

C13H13FO6 → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 10H-phenothiazine In sulfolane at 180℃; for 6h;	83.9%

C14H15FO6 → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 4-methoxy-phenol at 170℃; for 9h;	81.2%

C14H25FO5 → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 10H-phenothiazine at 170℃; for 15h;	81.2%

formaldehyd (50-00-0) + methyl fluoroacetate (453-18-9) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In dimethyl sulfoxide at 15 - 25℃; for 1h; Inert atmosphere; Stage #2: formaldehyd With 2,6-di-tert-butyl-4-methyl-phenol In dimethyl sulfoxide at 20 - 35℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;	79.3%
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In methanol; pentane at 20 - 25℃; for 24.25h; Claisen Condensation; Stage #2: formaldehyd In pentane at 5 - 10℃; for 5h; Concentration; Reagent/catalyst; Temperature; Time;	58%

methyl 2R,3S-2,3-difluoro-2,3-dichloropropionate (67832-56-8, 76497-87-5, 76548-29-3) → methyl 2-fluoroprop-2-enoate (2343-89-7) + methyl Z-α,β-difluoropropenoate (1660-56-6)

Conditions	Yield
With sulfuric acid; zinc at 100℃;	A 10% B 75%

methyl α,β-dibromo-α-fluoropropionate (380-26-7) → methyl 2-fluoroprop-2-enoate (2343-89-7) + acrylic acid methyl ester (292638-85-8)

Conditions	Yield
With thiourea; zinc In diphenylether at 95℃; under 20 Torr;	A 74% B n/a

C13H15FO7S → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol In sulfolane at 140℃; for 17h;	73.8%

methyl α-bromo-α-fluoropropionate → methyl 2-fluoroprop-2-enoate (2343-89-7) + methyl 2,2-difluoropropanoate (38650-84-9)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 50℃; for 48h; Solvent; Temperature; Reagent/catalyst; Cooling with ice;	A 23% B 73%

methanol (67-56-1) + 1-bromo-1-fluoroethylene (420-25-7) + carbon monoxide (201230-82-2) → 2-fluoroacrylic acid (430-99-9) + methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); triethylamine at 100℃; under 7500.75 Torr; for 13h; Autoclave;	A 14.1% B 70.9%

methyl α-bromo-α-fluoropropionate → methyl 2-fluoroprop-2-enoate (2343-89-7) + 2,2-difluoropropanoic acid (373-96-6) + methyl 2,2-difluoropropanoate (38650-84-9)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 72h; Reagent/catalyst; Solvent; Temperature; Cooling with ice;	A 18% B 5% C 70%

dimethyl 2-fluoro-2-(hydroxymethyl)malonate (107843-23-2) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With sulfolane; potassium fluoride; 2,6-di-tert-butyl-4-methyl-phenol at 90 - 105℃; under 760.051 Torr; for 1.25h;	70%
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; under 225.023 Torr;	24 g

methyl (2R,3R)-2,3-difluoro-2,3-dichloropropionate (76548-29-3) → methyl 2-fluoroprop-2-enoate (2343-89-7) + methyl Z-α,β-difluoropropenoate (1660-56-6) + methyl α,β-difluoroacrylate (76474-26-5)

Conditions	Yield
With sulfuric acid; zinc at 100℃;	A 10% B 64% C 10%

2,3-Dichlor-2-fluor-propansaeuremethylester (53510-07-9) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With sulfuric acid; water; zinc at 100 - 110℃;	52%

2,3-difluoropropionic acid methyl ester (4447-55-6) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With sodium fluoride at 30℃; for 3h;	46.9%

methanol (67-56-1) + Vinylidene fluoride (75-38-7) + carbon monoxide (201230-82-2) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
Stage #1: methanol With bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; lithium iodide In 1,4-dioxane at -78 - 30℃; for 1.5h; Autoclave; Sealed tube; Inert atmosphere; Stage #2: Vinylidene fluoride; carbon monoxide In 1,4-dioxane at 90℃; under 3000.3 Torr; for 24h; Concentration; Solvent; Temperature; Autoclave; Sealed tube;	5%

methyl 3-bromo-2-fluoropropionate (399-86-0) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With dimethyl amine In diethyl ether; benzene

cyclopenta-1,3-diene (542-92-7) → methyl 2-fluoroprop-2-enoate (2343-89-7) + (1S,2R,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester + (1R,2R,4R)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

Conditions	Yield
With thiourea; zinc 1.) diphenyl ether, 95 deg C, 20 Torr, 2.) room temperature; Yield given. Multistep reaction. Yields of byproduct given;

methyl α-bromo-α-fluoropropionate → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 10H-phenothiazine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 70℃; for 5h; Product distribution / selectivity;

formaldehyd (50-00-0) + C6H6FO5(1-)*Na(1+) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
Stage #1: C6H6FO5(1-)*Na(1+) In dimethyl sulfoxide for 0.333333h; Molecular sieve; Stage #2: formaldehyd In dimethyl sulfoxide at 40℃; for 1.5h; Molecular sieve;	19 g

1,1-dimethoxyethylene (922-69-0) + Dichlorofluoromethane (75-43-4) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
Stage #1: 1,1-dimethoxyethylene; Dichlorofluoromethane With tetrabutylammomium bromide; potassium hydroxide In hexane; water at 5 - 10℃; Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol at 0 - 145℃; under 360 Torr;

dimethyl 2-fluoro-2-chlorosulfinyloxymethylmalonate → methyl 2-fluoroprop-2-enoate (2343-89-7)

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 130℃; under 225.023 Torr; for 4h;

methyl 2-fluoroprop-2-enoate (2343-89-7) + 3-methoxy-1-iodobenzene (766-85-8) → (Z)-methyl 2-fluoro-3-(3-methoxyphenyl)acrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

ortho-methylphenyl iodide (615-37-2) + methyl 2-fluoroprop-2-enoate (2343-89-7) → (Z)-methyl 2-fluoro-3-(2-methylphenyl)acrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

methyl 2-fluoroprop-2-enoate (2343-89-7) + o-iodo-methyl-benzoic acid (610-97-9) → (Z)-methyl 2-(2-fluoro-3-methoxy-3-oxoprop-1-en-1-yl)benzoate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 2-iodonaphthalene (612-55-5) → (Z)-methyl 2-fluoro-3-(naphth-2-yl)acrylate (1075204-23-7)

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

iodobenzene (591-50-4) + methyl 2-fluoroprop-2-enoate (2343-89-7) → methyl (Z)-2-fluoro-3-phenylpropenoate (370-07-0, 56695-79-5, 56695-78-4)

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Reagent/catalyst; Temperature; Heck Reaction; stereospecific reaction;	99%
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Sealed tube; Inert atmosphere;

methyl 2-fluoroprop-2-enoate (2343-89-7) + 4-fluoro-1-iodobenzene (352-34-1) → (Z)-methyl 3-(4-fluorophenyl)-2-fluoroacrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 4-Iodobenzotrifluoride (455-13-0) → methyl Z-2-fluoro-3-(4-trifluoromethylphenyl)prop-2-enoate (126976-31-6)

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	99%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 2-6-dimethoxybenzoic acid (1466-76-8) → (Z)-methyl 2-fluoro-3-(2,6-dimethoxyphenyl)acrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;	98%

methyl 2-fluoroprop-2-enoate (2343-89-7) + octadec-1-ene (112-88-9) → methyl (Z)-2-fluorononadec-2-enoate

Conditions	Yield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;	98%

propylamine (107-10-8) + methyl 2-fluoroprop-2-enoate (2343-89-7) → N-(n-propyl)-α-fluoroacrylamide (1378386-19-6)

Conditions	Yield
In methanol at 20℃; for 24h;	96.14%

methyl 2-fluoroprop-2-enoate (2343-89-7) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → methyl 1-benzyl 3-fluoropyrrolidine-3-carboxylate (1279669-60-1)

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h;	95%
With trifluoroacetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere;	80%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;

methyl 2-fluoroprop-2-enoate (2343-89-7) + 1-(1,1-dimethylethyl)-1H-indole-1,2-dicarboxylic acid 2-methyl ester (163229-48-9) → C19H22FNO6

Conditions	Yield
With [Ir(dF(Me)ppy)2dtbbpy]PF6 In tetrahydrofuran at 28℃; Inert atmosphere; Glovebox; Irradiation;	93%

methyl 2-fluoroprop-2-enoate (2343-89-7) + (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2) → methyl 3-fluoro-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate (1461698-11-2)

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;	92%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 2-Methoxybenzoic acid (579-75-9) → methyl (2Z)-2-fluoro-3-(2-methoxyphenyl)acrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Time; Sealed tube; diastereoselective reaction;	92%

methyl 2-fluoroprop-2-enoate (2343-89-7) + N-methylaniline (100-61-8) → 3-fluoro-1-phenylpyrrolidin-2-one

Conditions	Yield
With Quinuclidine; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile for 16h; Sealed tube; Inert atmosphere; Irradiation;	92%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride (677728-84-6) → methyl 3-(3,5-difluorophenyl)-5-fluoro-4,5-dihydro-1,2-oxazole-5-carboxylate

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol at 40℃; for 1h;	91%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 4-iodobenzonitrile (3058-39-7) → methyl Z-3-(4-cyanophenyl)-2-fluoroprop-2-enoate (126976-32-7)

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;	90%
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Sealed tube; Inert atmosphere;

methyl 2-fluoroprop-2-enoate (2343-89-7) + 1,4-bromoiodobenzene (589-87-7) → (Z)-methyl 3-(4-bromophenyl)-2-fluoroacrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; chemoselective reaction;	89%

methyl 2-fluoroprop-2-enoate (2343-89-7) + mesitylenecarboxylic acid (480-63-7) → (Z)-methyl 2-fluoro-3-(2,4,6-trimethylphenyl)acrylate

Conditions	Yield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;	89%

methyl 2-fluoroprop-2-enoate (2343-89-7) → 2-fluoroacrylic acid (430-99-9)

Conditions	Yield
Stage #1: methyl 2-fluoroprop-2-enoate With sodium hydroxide In ethanol; water for 0.5h; pH=11; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water Inert atmosphere;	87%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 4-Phenyl-1-butene (768-56-9) → (Z)-methyl 2-fluoro-4-phenyl-2-butenoate (113924-47-3) + methyl (Z)-2-fluoro-5-phenylpent-2-enoate

Conditions	Yield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In chloroform at 80℃; for 15h; Reagent/catalyst; Solvent; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;	A n/a B 87%

methyl 2-fluoroprop-2-enoate (2343-89-7) + 1-(but-3-en-1-yl)-2-methoxybenzene (63667-83-4) → methyl (Z)-2-fluoro-5-(2-methoxyphenyl)pent-2-enoate

Conditions	Yield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;	87%

1-Decene (872-05-9) + methyl 2-fluoroprop-2-enoate (2343-89-7) → methyl (Z)-2-fluoroundeca-2-enoate

Conditions	Yield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;	87%

Upstream product

• 2365-93-7 methyl 3-bromo-2-fluoro-2-chloropropanoate 
• 542-92-7 cyclopenta-1,3-diene 
• 53510-07-9 2,3-Dichlor-2-fluor-propansaeuremethylester 
• 67-56-1 methanol 
• 420-25-7 1-bromo-1-fluoroethylene 
• 201230-82-2 carbon monoxide 
• 2317-91-1 1-chloro-1-fluoroethane 
• 107843-23-2 dimethyl 2-fluoro-2-(hydroxymethyl)malonate 
• 4447-55-6 2,3-difluoropropionic acid methyl ester 
• 922-67-8 propynoic acid methyl ester 
• 4538-50-5 methyl glycidate 
• 115781-23-2 1,2,3,3-tetrafluoro-2-propene 
• 50-00-0 formaldehyd 
• 344-14-9 dimethyl 2-fluoromalonate 

Downstream Products

• 1279669-60-1 methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate 
• 126976-31-6 methyl Z-2-fluoro-3-(4-trifluoromethylphenyl)prop-2-enoate 
• 113128-33-9 Methyl 2-fluoro-3-(4-methoxyphenyl)prop-2-enoate 
• 370-07-0 methyl (Z)-2-fluoro-3-phenylpropenoate 

Relevant articles and documents

SYNTHESIS OF METHYL 2-FLUOROACRYLATE

Methods for the synthesis of methyl 2-fluoroacrylate (MFA) are provided. The methods include use of various hydrofluorination agents using a variety of starting materials and reaction schemes. The methyl 2-fluoroacrylate prepared by the methods described herein can further be used to prepare patiromer calcium sorbitex.

METHOD OF PRODUCING HALOGENATED ACRYLIC ACID ESTER

PROBLEM TO BE SOLVED: To provide a method allowing production of a halogenated acrylic acid ester in a manner that is safe and convenient and is also suitable for industrial production, without using toxic ingredients. SOLUTION: A method of producing a compound represented by formula (4) includes reacting a compound represented by formula (1) with a compound represented by formula (2) in the presence of a base. [In the formulas, each symbol is as described in the specification.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Preparation method of methyl 2-fluoroacrylate

A preparation method of methyl 2-fluoroacrylate comprises the following steps: adding a solvent into a reaction kettle, dissolving methyl acrylate into the solvent, emptying, controlling the reactiontemperature in the reaction kettle, introducing fluorine gas, raising the temperature in the reaction kettle, removing HF under an alkaline condition to obtain a methyl 2-fluoroacrylate mother solution, and standing the mother solution; raising the temperature of the 2-fluoromethyl acrylate mother solution, and then carrying out hot filtration on the 2-fluoromethyl acrylate mother solution to obtain a 2-fluoromethyl acrylate filtrate; recrystallizing the 2-fluoromethyl acrylate filtrate to obtain crude 2-fluoromethyl acrylate; and rectifying the crude 2-fluoromethyl acrylate, and collecting the obtained fraction to obtain pure 2-fluoromethyl acrylate. The method has low requirements on equipment, can effectively inhibit the activity of F2 and reduce the generation of byproducts, can improve the yield and purity of the product, and can effectively remove the reaction raw materials and the solvent to obtain the high-purity methyl 2-fluoroacrylate.