L-Glutamic acid 5-cyclohexyl ester

Base Information

• Chemical Name: L-Glutamic acid 5-cyclohexyl ester
• CAS No.: 112471-82-6
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Hs Code.: 2922509090
• Mol file: 112471-82-6.mol

Synonyms:g-Cyclohexyl glutamate;H-Glu(OcHex)-OH;

Chemical Property of L-Glutamic acid 5-cyclohexyl ester

Chemical Property:

• Vapor Pressure: 1.51E-07mmHg at 25°C
• Refractive Index: 1.507
• Boiling Point: 400.9 °C at 760 mmHg
• PKA: 2.20±0.10(Predicted)
• Flash Point: 196.2 °C
• PSA: 89.62000
• Density: 1.17 g/cm³
• LogP: 1.75470
• Storage Temp.: Store at 0-5°C

Purity/Quality:

99% ^*data from raw suppliers

(2s)-2-Azaniumyl-5-cyclohexyloxy-5-oxopentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid 5-cyclohexyl ester

There total 1 articles about L-Glutamic acid 5-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + cyclohexanol (108-93-0) → γ-cyclohexyl L-glutamate (112471-82-6)

Guidance literature:

With tetrafluoroboric acid diethyl ether; sodium sulfate; for 15h; Ambient temperature;

DOI:10.1055/s-1987-28030

Reference yield: 100.0%

γ-cyclohexyl L-glutamate (112471-82-6) → (S)-2-hydroxy-pentanedioic acid 5-cyclohexyl ester

Guidance literature:

With sodium nitrite; In water; acetic acid; at 25 ℃; for 3h;

DOI:10.1021/ol036102m

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + γ-cyclohexyl L-glutamate (112471-82-6) → N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester (73821-97-3,133464-27-4)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In N,N-dimethyl-formamide; for 12h; Yield given; Ambient temperature;

DOI:10.1055/s-1992-26108

upstream raw materials:

L-glutamic acid

cyclohexanol

Downstream raw materials:

N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester

Refernces

• 1、 Albert, Rainer,Danklmaier, Johann,Hoenig, Helmut,Kandolf, Harald. "A Simple and Convenient Synthesis of β-Aspartates and γ-Glutamates". . p. 635 - 637. Retrieved 2007/10/02.