Hydrazinecarboximidamide,2-cyclohexylidene-

Base Information

• Chemical Name: Hydrazinecarboximidamide,2-cyclohexylidene-
• CAS No.: 4364-74-3
• Molecular Formula: C7H14 N4
• Molecular Weight: 154.215
• Mol file: 4364-74-3.mol

Synonyms:Guanidine,(cyclohexylideneamino)- (7CI,8CI); (Cyclohexylideneamino)guanidine;Cyclohexanone amidinohydrazone; Cyclohexanone, (aminoiminomethyl)hydrazone; NSC67476

Chemical Property of Hydrazinecarboximidamide,2-cyclohexylidene-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrazinecarboximidamide,2-cyclohexylidene-

There total 5 articles about Hydrazinecarboximidamide,2-cyclohexylidene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + aminoguanidine nitrate (10308-82-4) → 2-cyclohexylidene-1-hydrazinecarboximidamide (4364-74-3)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1080/10426500903329237

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 1-aminoguanidine hydrochloride (1937-19-5,16139-18-7) → 2-cyclohexylidene-1-hydrazinecarboximidamide (4364-74-3)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01132a007

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + aminoguanidine (79-17-4) → 2-cyclohexylidene-1-hydrazinecarboximidamide (4364-74-3)

Guidance literature:

With acetic acid; In ethanol; for 12h; Reflux;

DOI:10.2174/1573406417666210216154428

upstream raw materials:

cyclohexanone

1-aminoguanidine hydrochloride

aminoguanidine bicarbonate

aminoguanidine nitrate

Downstream raw materials:

N-(cyclohexylideneamino)-N'-(phenylthiocarbamoyl)guanidine

N-(p-chlorophenylthiocarbamoyl)-N'-(cyclohexylideneamino)guanidine

cyclohexanone

aminoguanidine

Refernces

• 1、 Titus, Sarah,Sreejalekshmi, Kumaran G.. "Enriching biologically relevant chemical space around 2-aminothiazole template for anticancer drug development". . p. 23 - 36. Retrieved 2018/04/19.
• 2、 Sreejalekshmi. "A facile, sequential multicomponent approach to N-aminoamidinothioureas- versatile synthons to bioactive heterocycles". experimental part. p. 1830 - 1837. Retrieved 2010/11/16.