2-Bromo-3-methyl-5-chloropyridine

Base Information

• Chemical Name: 2-Bromo-3-methyl-5-chloropyridine
• CAS No.: 65550-77-8
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.469
• Hs Code.: 2933399090
• Mol file: 65550-77-8.mol

Synonyms:2-Bromo-3-methyl-5-chloropyridine;2-Bromo-5-chloro-3-methylpyridine;2-Bromo-5-chloro-3-picoline;

Chemical Property of 2-Bromo-3-methyl-5-chloropyridine

Chemical Property:

• Vapor Pressure: 0.0593mmHg at 25°C
• Melting Point: 40-44 °C
• Refractive Index: 1.571
• Boiling Point: 240.3 °C at 760 mmHg
• PKA: -1.20±0.20(Predicted)
• Flash Point: 99.1 °C
• PSA: 12.89000
• Density: 1.624
• LogP: 2.80590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-chloro-3-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 37/39-26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-methyl-5-chloropyridine

There total 2 articles about 2-Bromo-3-methyl-5-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 2-bromine-3-methyl-5-chloropyridine (65550-77-8)

Guidance literature:

With hydrogen bromide; bromine; sodium nitrite; Multistep reaction; 1.) chlorination; 2.) water, -10 deg C, 1.5 h, 0 deg C, 0.5 h;

DOI:10.1016/0223-5234(89)90006-8

Reference yield:

→ 2-bromine-3-methyl-5-chloropyridine (65550-77-8)

Guidance literature:

5-Amino-2-bromo-3-picolin II 1.)Diazotierung 2.)HCl;

DOI:10.1016/S1352-2310(00)00235-1

Reference yield: 76.0%

zinc(II) cyanide (557-21-1) + 2-bromine-3-methyl-5-chloropyridine (65550-77-8) → 5-chloro-3-methylpyridine-2-carbonitrile (156072-84-3)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 110 ℃; for 4h;

upstream raw materials:

3-methylpyridin-2-ylamine

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methylpyridine-2-carbothioamide

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methyl-2-pyridinecarboxamide

5-chloro-3-methylpyridine-2-carboxylic acid

N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-methylpicolinamide

Refernces