4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE

Base Information

• Chemical Name: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE
• CAS No.: 162208-27-7
• Molecular Formula: C₁₀H₁₆N₃O₅PS₂
• Molecular Weight: 353.36
• Mol file: 162208-27-7.mol

Synonyms:4-Thiazoleaceticacid, 2-amino-a-(methoxyimino)-,anhydride with O,O-diethyl hydrogen phosphorothioate, (Z)-;(Z)-Diethylthiophosphoryl (2-aminothiazol-4-yl)-a-(methoxyimino)acetate;

Chemical Property of 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE

Chemical Property:

• Vapor Pressure: 3.23E-08mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 448 °C at 760 mmHg
• PKA: 1.26±0.10(Predicted)
• Flash Point: 224.7 °C
• PSA: 175.40000
• Density: 1.49 g/cm³
• LogP: 3.14830

Purity/Quality:

99.9% ^*data from raw suppliers

DIETHYL THIOPHOSPHORIL (Z)-(2-AMINOTHIAZOL-4-YL)-(METHOXYIMINO)ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: The compound 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE appears to be a complex chemical with potential applications in various fields. However, without specific context or knowledge of its proprietary name or commonly recognized use, it is challenging to pinpoint its exact uses and roles in different fields. The combination of thiazole, amino, and phosphorothioate groups suggests that it could potentially have applications in pharmaceuticals, pesticides, or organic synthesis, but a precise description of its uses and roles would require more specific information about the compound's identity and intended applications.

Technology Process of 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE

There total 1 articles about 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-, (AZ)-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cefotaxime (65872-41-5) + diethyl phosphorochloridothioate (2524-04-1) → diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate (162208-27-7)

Guidance literature:

With tributyl-amine; triethylamine; In dichloromethane; at 0 - 5 ℃; for 3h; Inert atmosphere;

DOI:10.1515/hc-2014-0048

Reference yield: 92.8%

diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate (162208-27-7) + 7-aminoceftrizine (58909-56-1) → ceftriaxone (73384-59-5,92143-31-2)

Guidance literature:

With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine; In ethanol; dichloromethane; at 0 - 5 ℃; for 4h;

DOI:10.1515/hc-2014-0048

upstream raw materials:

cefotaxime

diethyl phosphorochloridothioate

Downstream raw materials:

ceftriaxone

Refernces