Technology Process of tert-butyl 2-[2-methoxy-4-(1,6-naphthyridin-4-yloxy)phenyl]acetate
There total 6 articles about tert-butyl 2-[2-methoxy-4-(1,6-naphthyridin-4-yloxy)phenyl]acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap;
In
chlorobenzene;
at 130 ℃;
for 8h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 24 h / 85 °C
1.2: 20 °C / pH 2
2.1: toluene / 1 h / 90 - 95 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol; ethanol; ethyl acetate / 3 h / 1292.09 Torr
4.1: dmap / chlorobenzene / 8 h / 130 °C
With
methanol; dmap; sodium hydroxide; water; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate; chlorobenzene; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / methanol; 1,2-dimethoxyethane / 3 h / -78 °C / Heating / reflux
2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 24 h / 85 °C
2.2: 20 °C / pH 2
3.1: toluene / 1 h / 90 - 95 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol; ethanol; ethyl acetate / 3 h / 1292.09 Torr
5.1: dmap / chlorobenzene / 8 h / 130 °C
With
methanol; dmap; sodium hydroxide; potassium tert-butylate; water; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; ethyl acetate; chlorobenzene; toluene;