2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate

Base Information

• Chemical Name: 2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate
• CAS No.: 150321-92-9
• Molecular Formula: C₁₅H₁₁NO₇
• Molecular Weight: 317.255
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00375220
• Nikkaji Number: J2.170.003G
• Wikidata: Q72509070
• Mol file: 150321-92-9.mol

Synonyms:150321-92-9;2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate;7-Methoxycoumarin-3-carboxylic acid N-succinimidyl ester;(2,5-dioxopyrrolidin-1-yl) 7-methoxy-2-oxochromene-3-carboxylate;N-Succinimidyl 7-methoxycoumarin-3-carboxylate;7-Methoxycoumarin-3-carboxylic acid, SE;Succinimidyl 7-methoxycoumarin-3-carboxylate;2H-1-Benzopyran-3-carboxylic acid, 7-methoxy-2-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;N-SUCCINIMIDYL7-METHOXYCOUMARIN-3-CARBOXYLATE;SCHEMBL591072;DTXSID00375220;JMQAALOXLOSYCQ-UHFFFAOYSA-N;HY-D1083;MFCD00467593;AKOS015911915;AM84462;7-Methoxycoumarin-3-carboxylic acid-NHS;AS-73955;CS-0114629;FT-0714071;S0867;Succinimidyl 7-methoxy-2H-chromene-3-carboxylate;A884168;F05-0015;J-100199;7-Methoxycoumarin-3-carbonic acid N-succinimidyl ester;7-methoxycoumarin-3-carboxylic acid succinimidyl ester;7-methoxycoumarin-3-carboxylic acid-succinimidyl ester;7-Methoxycoumarin-3-carboxylicacid,succinimidyl ester;7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester;2-Oxo-7-methoxy-2H-1-benzopyran-3-carboxylic acid succinimidyl ester;7-Methoxycoumarin-3-carboxylic acid N-succinimidyl ester, suitable for fluorescence, >=97.0% (HPLC)

Chemical Property of 2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate

Chemical Property:

• Vapor Pressure: 5.19E-11mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 522.4 °C at 760 mmHg
• Flash Point: 269.8 °C
• PSA: 103.12000
• Density: 1.54 g/cm³
• LogP: 0.96030
• Storage Temp.: −20°C
• Solubility.: DMF: soluble
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 317.05355169
• Heavy Atom Count: 23
• Complexity: 581

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Methoxycoumarin-3-carboxylicAcidN-SuccinimidylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)ON3C(=O)CCC3=O
• Uses: N-Succinimidyl 7-Methoxycoumarin-3-carboxylate is used for labelling neuropeptides and other peptides. 7-Methoxycoumarin-3-carboxylic Acid N-Succinimidyl Ester (cas# 150321-92-9) is a compound useful in organic synthesis.

Technology Process of 2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate

There total 1 articles about 2,5-Dioxopyrrolidin-1-yl 7-methoxy-2-oxo-2H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 7-methoxycoumarin-3-carboxylic acid (20300-59-8) → 2,5-dioxotetrahydro-1H-1-pyrrolyl-7-methoxy-2-oxo-2H-3-chromene carboxylate (150321-92-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 40 ℃;

DOI:10.1039/c0ob01042a

Reference yield:

substance P (71977-09-8) + 2,5-dioxotetrahydro-1H-1-pyrrolyl-7-methoxy-2-oxo-2H-3-chromene carboxylate (150321-92-9) → C74H103N17O18S (916168-89-3)

Guidance literature:

for 1h;

DOI:10.1021/ja207736y

Reference yield:

angiotensin I (484-42-4) + 2,5-dioxotetrahydro-1H-1-pyrrolyl-7-methoxy-2-oxo-2H-3-chromene carboxylate (150321-92-9) → C73H95N17O18

Guidance literature:

for 1h;

DOI:10.1021/ja207736y

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

7-methoxycoumarin-3-carboxylic acid

Downstream raw materials:

C₇₄H₁₀₃N₁₇O₁₈S

Refernces

• 1、 H?u?ler, Daniela,Gütschow, Michael. "Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules". . p. 245 - 255. Retrieved 2016/01/15.
• 2、 Yoon, Hyung-Jo,Dakanali, Marianna,Lichlyter, Darcy,Chang, Willy M.,Nguyen, Karen A.,Nipper, Matthew E.,Haidekker, Mark A.,Theodorakis, Emmanuel A.. "Synthesis and evaluation of self-calibrating ratiometric viscosity sensors". supporting information; experimental part. p. 3530 - 3540. Retrieved 2011/06/25.