methyl 3-(4-chlorophenyl)-3-oxopropanedithioate

Base Information

• Chemical Name: methyl 3-(4-chlorophenyl)-3-oxopropanedithioate
• CAS No.: 83392-36-3
• Molecular Formula: C₁₀H₉ClOS₂
• Molecular Weight: 244.766
• Mol file: 83392-36-3.mol

Synonyms:methyl 3-(4-chlorophenyl)-3-oxopropanedithioate

Chemical Property of methyl 3-(4-chlorophenyl)-3-oxopropanedithioate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-(4-chlorophenyl)-3-oxopropanedithioate

There total 2 articles about methyl 3-(4-chlorophenyl)-3-oxopropanedithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one (41467-26-9) → methyl 3-(4-chlorophenyl)-3-oxopropanedithioate (83392-36-3)

Guidance literature:

With boron trifluoride diethyl etherate; hydrogen sulfide; In 1,4-dioxane; for 2.5h; Heating;

DOI:10.1080/00397919908086034

Reference yield: 75.0%

(S,S)-dimethyl trithiocarbonate (2314-48-9) + para-chloroacetophenone (99-91-2) → methyl 3-(4-chlorophenyl)-3-oxopropanedithioate (83392-36-3)

Guidance literature:

With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo101572c

Reference yield: 95.0%

methyl 3-(4-chlorophenyl)-3-oxopropanedithioate (83392-36-3) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 3-(4-chlorobenzoyl)-8-methoxy-2H-chromene-2-thione (1228956-77-1)

Guidance literature:

With piperidine; at 90 ℃;

DOI:10.1016/j.ejmech.2010.01.070

upstream raw materials:

(S,S)-dimethyl trithiocarbonate

para-chloroacetophenone

1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one

Downstream raw materials:

2-(Bis-methylsulfanyl-methylene)-1-(4-chloro-phenyl)-4-methyl-pent-4-en-1-one

ethyl 2-{[(Z)3-(4-chlorophenyl)-3-hydroxy-2-propene-1-thione]amino}acetate

methyl 2-{[3-(4-chlorophenyl)-3-oxopropanthioyl]amino}acetate

5-(4'-chlorophenyl)-3-(methylthio)-1-phenyl-1H-pyrazole

Refernces

• 1、 Srivastava, Abhijeet,Shukla, Gaurav,Yadav, Dhananjay,Singh, Maya Shankar. "Access to Fully Substituted Thiazoles and 2,3-Dihydrothiazoles via Copper-Catalyzed [4 + 1] Heterocyclization of α-(N-Hydroxy/aryl)imino-β-oxodithioesters with α-Diazocarbonyls". supporting information. p. 10846 - 10854. Retrieved 2017/10/27.
• 2、 Devi, Nepram Sushuma,Singh, Sarangthem Joychandra,Devi, Laishram Ronibala,Singh, Okram Mukherjee. "Facile route to highly functionalized 2H-chromene-2-thiones via ring annulations of β-oxodithioesters with phenols catalyzed by AlCl3 under solvent-free conditions". . p. 183 - 187. Retrieved 2013/02/21.