4-(4-Aminophenoxy)pyridine

Base Information

• Chemical Name: 4-(4-Aminophenoxy)pyridine
• CAS No.: 102877-78-1
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Hs Code.: 2933399090
• Mol file: 102877-78-1.mol

Synonyms:Pyridine,4-(p-aminophenoxy)- (6CI);4-(4-Pyridinyloxy)aniline;4-(Pyridin-4-yloxy)phenylamine;Benzenamine,4-(4-pyridinyloxy)-;

Chemical Property of 4-(4-Aminophenoxy)pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 160-162 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.626
• Boiling Point: 346.227 ºC at 760 mmHg
• PKA: 6.63±0.10(Predicted)
• Flash Point: 163.192 ºC
• PSA: 48.14000
• Density: 1.197 g/cm³
• LogP: 3.03730
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(Pyridin-4-yloxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Aminophenoxy)pyridine

There total 13 articles about 4-(4-Aminophenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitrophenyl-4-pyridyl ether (4783-83-9) → 4-(4-pyridinyloxy)aniline (102877-78-1)

Guidance literature:

With palladium 10% on activated carbon; In ethyl acetate; under 2844.39 Torr; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00700

Reference yield: 94.0%

4-chlorpyridine hydrochloride (7379-35-3) + 4-amino-phenol (123-30-8) → 4-(4-pyridinyloxy)aniline (102877-78-1)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 100 ℃; for 18h;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 4-(4-pyridinyloxy)aniline (102877-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 180 - 200 °C

2: tin (II)-chloride; hydrochloric acid; water

With hydrogenchloride; water; tin(ll) chloride;

upstream raw materials:

4-nitrophenyl-4-pyridyl ether

1-(4-pyridyl)pyridinium chloride hydrochloride

4-amino-phenol

4-Chloropyridine

Downstream raw materials:

4-(4-pyridinyloxy)phenyl-thioisocyanate

4-nitrophenyl 4-(pyridin-4-yloxy)phenylcarbamate

N-[3-(tert-butyl)-1-methylpyrazol-5-yl][(4-(4-pyridyloxy)phenyl)amino]carboxamide

Refernces

• 1、 -. "MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF". Page/Page column 84. . Retrieved 2019/12/25.
• 2、 -. "COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS". Page/Page column 32. . Retrieved 2014/11/13.