3,4-Diethoxybenzohydrazide

Base Information

• Chemical Name: 3,4-Diethoxybenzohydrazide
• CAS No.: 380482-31-5
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Hs Code.: 2928000090
• European Community (EC) Number: 674-271-4
• DSSTox Substance ID: DTXSID80374231
• Wikidata: Q82162748
• Mol file: 380482-31-5.mol

Synonyms:3,4-Diethoxybenzohydrazide;3,4-Diethoxybenzhydrazide;380482-31-5;SCHEMBL17141817;DTXSID80374231;BBL017598;MFCD01310808;STK463044;AKOS000150797;3,4-Diethoxybenzohydrazide, AldrichCPR;VS-06315;CS-0314062;FT-0676389;A823992

Chemical Property of 3,4-Diethoxybenzohydrazide

Chemical Property:

• Melting Point: 164-166 ºC
• Refractive Index: 1.532
• PSA: 73.58000
• Density: 1.132 g/cm³
• LogP: 2.17870
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 224.11609238
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

98%min ^*data from raw suppliers

3,4-Diethoxybenzohydrazide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36-22
• Safety Statements: 36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)C(=O)NN)OCC

Technology Process of 3,4-Diethoxybenzohydrazide

There total 2 articles about 3,4-Diethoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,4-diethoxybenzoic acid ethyl ester (75332-44-4) → 3,4-diethoxybenzohydrazide (380482-31-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2018.02.054

Reference yield:

3,4-diethoxybenzoic acid (5409-31-4) → 3,4-diethoxybenzohydrazide (380482-31-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2018.02.054

upstream raw materials:

3,4-diethoxybenzoic acid

3,4-diethoxybenzoic acid ethyl ester

Refernces