Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid

Base Information

• Chemical Name: Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid
• CAS No.: 711-02-4
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Hs Code.: 2917209090
• Mol file: 711-02-4.mol

Synonyms:1,4-bicyclo<2.2.2>octanedicarboxylic acid;1,4-dicarboxybicyclo[2.2.2]octane;bicyclo[2.2.2]octane-1,4-dicarboxylyc acid;Bicyclo[2.2.2]octane-1,4-dicarboxylicacid;Bicyclo[2.2.2]octan-1,4-dicarbonsaeure;

Chemical Property of Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid

Chemical Property:

• Vapor Pressure: 2.86E-07mmHg at 25°C
• Melting Point: 393-395ºC
• Refractive Index: 1.601
• Boiling Point: 392.9 °C at 760 mmHg
• PKA: 4.49±0.10(Predicted)
• Flash Point: 205.6 °C
• PSA: 74.60000
• Density: 1.447 g/cm³
• LogP: 1.49620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Bicyclo[2.2.2]octane-1,4-dicarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid

There total 25 articles about Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate (1459-96-7) → 1,4-bicyclo[2.2.2]octanedicarboxylic acid (711-02-4)

Guidance literature:

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate; With lithium hydroxide; water; isopropyl alcohol; In tetrahydrofuran; at 60 - 70 ℃; for 2.5h;

With hydrogenchloride; In water; at 0 ℃;

Reference yield: 87.0%

1,4-dihydroxybicyclo[2.2.2]octane (1194-44-1) + carbon monoxide (201230-82-2) → 1,4-bicyclo[2.2.2]octanedicarboxylic acid (711-02-4)

Guidance literature:

With fuming sulphuric acid; at 23 ℃; for 16h; under 104192 Torr; Autoclave;

Reference yield: 82.0%

1,4-dicyanobicyclo(2.2.2)octane (41034-58-6) → 1,4-bicyclo[2.2.2]octanedicarboxylic acid (711-02-4)

Guidance literature:

With potassium hydroxide; In methanol; Heating;

upstream raw materials:

Bicyclo<2.2.2>octane-1,4-dimethanol

Bicyclo<2.2.2.>octan-1,4-dicarbonsauere-ethylester

1,4-dicyanobicyclo(2.2.2)octane

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

Downstream raw materials:

1,4-dibromobicyclo<2.2.2>octane

(4-Hydroxymethyl-bicyclo[2.2.2]oct-1-yl)-methanol

1,4-dichlorobicyclo<2.2.2>octane

1,4-diaminobicyclo[2.2.2]octane dihydrochloride

Refernces

• 1、 -. "SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES". Paragraph 0088; 0090. . Retrieved 2019/05/02.
• 2、 -. "Bicyclo [2.2.2] octane - 1, 4 - dicarboxylic acid mono methyl ester synthesis method". . . Retrieved 2017/07/07.