2-(4-methylphenyl)pyrazine

Base Information

• Chemical Name: 2-(4-methylphenyl)pyrazine
• CAS No.: 108030-80-4
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.214
• Mol file: 108030-80-4.mol

Synonyms:2-(4-methylphenyl)pyrazine

Chemical Property of 2-(4-methylphenyl)pyrazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylphenyl)pyrazine

There total 23 articles about 2-(4-methylphenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloropyrazin (14508-49-7) + 4-methylphenylboronic acid (5720-05-8) → 2-(4-methylphenyl)pyrazine (108030-80-4)

Guidance literature:

With potassium phosphate tribasic heptahydrate; palladium diacetate; In ethylene glycol; at 80 ℃; for 0.333333h;

DOI:10.1002/ejoc.201000962

Reference yield: 90.0%

1,4-pyrazine (290-37-9) + 4-methylphenylboronic acid (5720-05-8) → 2-(4-methylphenyl)pyrazine (108030-80-4)

Guidance literature:

1,4-pyrazine; With Iron(III) nitrate nonahydrate; dipotassium peroxodisulfate; trifluoroacetic acid; In water; at 20 ℃; for 0.166667h; Schlenk technique;

4-methylphenylboronic acid; In water; at 70 ℃; for 24h; Schlenk technique;

DOI:10.1002/ejoc.201300743

Reference yield: 87.0%

2-(phenylsulfanyl)pyrazine (107697-83-6) + para-methylphenylmagnesium bromide (4294-57-9) → 2-(4-methylphenyl)pyrazine (108030-80-4)

Guidance literature:

2-(phenylsulfanyl)pyrazine; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; Inert atmosphere;

para-methylphenylmagnesium bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo901327y

upstream raw materials:

1-(2,2-dibromovinyl)-4-methylbenzene

ethylenediamine

2-p-tolylpyrazine 1-oxide

4-methylphenylglyoxal

Downstream raw materials:

(RS)-2-(4-methylphenyl)piperazine

Refernces

• 1、 Silva, Rodrigo C.,Villela, Lucas F.,Brocksom, Timothy J.,De Oliveira, Kleber T.. "Direct C-H photoarylation of diazines using aryldiazonium salts and visible-light". . p. 31115 - 31122. Retrieved 2020/09/23.
• 2、 Singh, Bhagat,Paira, Rupankar,Biswas, Goutam,Shaw, Bikash Kumar,Mandal, Swadhin K.. "Graphene oxide-phenalenyl composite: transition metal-free recyclable and catalytic C-H functionalization". supporting information. p. 13220 - 13223. Retrieved 2018/12/10.