2-p-tolylpiperazine

Base Information

• Chemical Name: 2-p-tolylpiperazine
• CAS No.: 65709-31-1
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• Hs Code.: 2933599090
• Mol file: 65709-31-1.mol

Synonyms:2-(4-tolyl)-piperazin;2-p-tolylpiperazine;2-(4-Tolyl)piperazine;2-(4-methylphenyl)-piperazine;

Chemical Property of 2-p-tolylpiperazine

Chemical Property:

• Melting Point: 88.7-90.3 °C
• Boiling Point: 308.9±32.0 °C(Predicted)
• PKA: 8.87±0.40(Predicted)
• PSA: 24.06000
• Density: 0.984±0.06 g/cm3(Predicted)
• LogP: 1.88650
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methylphenyl)piperazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-p-tolylpiperazine

There total 5 articles about 2-p-tolylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-methylphenyl)pyrazine (108030-80-4) → (RS)-2-(4-methylphenyl)piperazine (65709-31-1)

Guidance literature:

With triphenylborane; diphenylsilane; diphenylamine; In toluene; at 110 ℃; for 24h; chemoselective reaction; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201702304

Reference yield: 87.0%

C25H28N2 (1421004-98-9) → (RS)-2-(4-methylphenyl)piperazine (65709-31-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 4h;

DOI:10.1016/j.tetlet.2012.11.110

Reference yield: 68.0%

2-p-tolylpyrazine 1-oxide (922524-99-0) → (RS)-2-(4-methylphenyl)piperazine (65709-31-1)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; at 20 ℃; for 4h;

DOI:10.1002/anie.200602773

upstream raw materials:

2-p-tolylpyrazine 1-oxide

1-ethenyl-4-methylbenzene

C₂₅H₂₈N₂

2-(4-methylphenyl)pyrazine

Refernces

• 1、 Kour, Harpreet,Paul, Satya,Singh, Parvinder Pal,Gupta, Monika,Gupta, Rajive. "A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins". . p. 761 - 764. Retrieved 2013/02/25.
• 2、 Leclerc, Jean-Philippe,Fagnou, Keith. "Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides". . p. 7781 - 7786. Retrieved 2007/10/03.