Technology Process of N-α-Boc-N-ε-EDTA(Bn)3-L-Lys
There total 6 articles about N-α-Boc-N-ε-EDTA(Bn)3-L-Lys which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 12 h / Ambient temperature
2: 94 percent / piperidine / 2 h / Ambient temperature
3: 91 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 23 h / Ambient temperature
4: 99 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 0.05 h
With
piperidine; dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81787-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 23 h / Ambient temperature
2: 99 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 0.05 h
With
dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81787-7