N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester

Base Information

• Chemical Name: N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester
• CAS No.: 134020-69-2
• Molecular Formula: C₄₇H₆₆N₄O₁₁Si
• Molecular Weight: 891.147
• Mol file: 134020-69-2.mol

Synonyms:N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester

Chemical Property of N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester

There total 5 articles about N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-α-Boc-L-Lys-O-Tmse ester (134020-68-1) + Tribenzyl EDTA (134020-65-8) → N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester (134020-69-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 23h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81787-7

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) → N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester (134020-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 12 h / Ambient temperature

2: 94 percent / piperidine / 2 h / Ambient temperature

3: 91 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 23 h / Ambient temperature

With piperidine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)81787-7

Reference yield:

Boc-Lys(Fmoc)-OH (84624-27-1) → N-α-Boc-N-ε-EDTA(Bn)3-L-Lys-O-Tmse ester (134020-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 12 h / Ambient temperature

2: 94 percent / piperidine / 2 h / Ambient temperature

3: 91 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 23 h / Ambient temperature

With piperidine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)81787-7

upstream raw materials:

N-α-Boc-L-Lys-O-Tmse ester

Tribenzyl EDTA

2-(Trimethylsilyl)ethanol

Boc-Lys(Fmoc)-OH

Downstream raw materials:

N-α-Boc-N-ε-EDTA(Bn)3-L-Lys

Refernces