Methyl 6-fluoropicolinate

Base Information

• Chemical Name: Methyl 6-fluoropicolinate
• CAS No.: 455-71-0
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.129
• Hs Code.: 2933399090
• Mol file: 455-71-0.mol

Synonyms:Picolinicacid, 6-fluoro-, methyl ester (8CI);

Chemical Property of Methyl 6-fluoropicolinate

Chemical Property:

• Melting Point: 51-55 °C
• Refractive Index: 1.49
• Boiling Point: 246 °C at 760 mmHg
• PKA: -1.23±0.10(Predicted)
• Flash Point: 102.6 °C
• PSA: 39.19000
• Density: 1.243 g/cm³
• LogP: 1.00730
• Storage Temp.: Room temperature.

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 6-fluoropicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-fluoropicolinate

Technology Process of Methyl 6-fluoropicolinate

There total 6 articles about Methyl 6-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-fluoropyridine-2-carboxylic acid (402-69-7) + methyl iodide (74-88-4) → methyl 6-fluoropyridine-2-carboxylate (455-71-0)

Guidance literature:

With silver carbonate; In chloroform; at 20 ℃; for 24h;

Reference yield: 75.0%

methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) → methyl 6-fluoropyridine-2-carboxylate (455-71-0)

Guidance literature:

With silver(II) fluoride; In acetonitrile; at 20 ℃; Inert atmosphere; Autoclave;

DOI:10.1021/acs.organomet.9b00469

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → methyl 6-fluoropyridine-2-carboxylate (455-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; aqueous tetrafluoroboric acid

2: H₂O; KMnO₄

With potassium permanganate; tetrafluoroboric acid; water; sodium nitrite;

DOI:10.1021/ja01180a511

upstream raw materials:

diazomethane

6-fluoropyridine-2-carboxylic acid

2-Amino-6-methylpyridine

2-fluoro-6-methylpyridine

Downstream raw materials:

6-fluoropyridine-2-carboxamide

2-Fluoropyridine-6-carboxaldehyde

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY". Page/Page column 118-119. . Retrieved 2019/09/18.
• 2、 -. "QUINOLINE DERIVATIVES AS SMO INHIBITORS". Paragraph 0554; 0555. . Retrieved 2017/02/28.