2-bromo-4-chloro-1-ethynylbenzene

Base Information

• Chemical Name: 2-bromo-4-chloro-1-ethynylbenzene
• CAS No.: 1350535-10-2
• Molecular Formula: C₈H₄BrCl
• Molecular Weight: 215.477
• Mol file: 1350535-10-2.mol

Synonyms:2-bromo-4-chloro-1-ethynylbenzene

Chemical Property of 2-bromo-4-chloro-1-ethynylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-bromo-4-chloro-1-ethynylbenzene

There total 4 articles about 2-bromo-4-chloro-1-ethynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-5-chloro-2-(2,2-dibromovinyl)benzene (1243602-20-1) → 2-bromo-4-chloro-1-ethynylbenzene (1350535-10-2)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 115 ℃; for 8h;

DOI:10.1055/s-0037-1610739

Reference yield:

2-bromo-4-chloro-1-[2-(trimethylsilyl)ethynyl]benzene → 2-bromo-4-chloro-1-ethynylbenzene (1350535-10-2)

Guidance literature:

With methanol; potassium carbonate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/asia.201800516

Reference yield:

2-bromo-4-chloroiodobenzene (31928-44-6) → 2-bromo-4-chloro-1-ethynylbenzene (1350535-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 20 °C / Inert atmosphere

2: potassium carbonate; methanol / dichloromethane / 2 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; diethylamine; In dichloromethane;

DOI:10.1002/asia.201800516

upstream raw materials:

2-bromo-4-chloroiodobenzene

2-bromo-4-chlorobenzaldehyde

1-bromo-5-chloro-2-(2,2-dibromovinyl)benzene

Downstream raw materials:

C₂₂H₁₃ClO₂S₂

Refernces

• 1、 Wang, Chun-Hai,Yang, Shang-Dong. "Rh(III)-Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3-Phosphinoylindoles". supporting information. p. 2401 - 2404. Retrieved 2018/09/10.