2-(3-BORONOPHENYL)-5-METHYL-1,3,4-OXADIAZOLE

Base Information

• Chemical Name: 2-(3-BORONOPHENYL)-5-METHYL-1,3,4-OXADIAZOLE
• CAS No.: 913836-04-1
• Molecular Formula: C9H9BN2O3
• Molecular Weight: 203.993
• Hs Code.: 2934999090
• Mol file: 913836-04-1.mol

Synonyms:Boronic acid, [3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-(9CI);

Chemical Property of 2-(3-BORONOPHENYL)-5-METHYL-1,3,4-OXADIAZOLE

Chemical Property:

• Vapor Pressure: 8.34E-09mmHg at 25°C
• Melting Point: 160-162
• Refractive Index: 1.585
• Boiling Point: 447.8 °C at 760 mmHg
• Flash Point: 224.7 °C
• PSA: 79.38000
• Density: 1.34g/cm³
• LogP: -0.27520

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-Boronophenyl)-5-methyl-1,3,4-oxadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-BORONOPHENYL)-5-METHYL-1,3,4-OXADIAZOLE

There total 1 articles about 2-(3-BORONOPHENYL)-5-METHYL-1,3,4-OXADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ [3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]boronic acid (913836-04-1)

Guidance literature:

Reference yield: 59.0%

[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]boronic acid (913836-04-1) + C25H32BrNO4 (1390665-75-4) → C34H39N3O5 (1390666-38-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.05.124

Reference yield: 37.0%

2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl trifluoromethanesulfonate (1217340-76-5) + [3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]boronic acid (913836-04-1) → 2-(4-fluorophenyl)-N-methyl-5-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)benzofuran-3-carboxamide (1217339-35-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; Product distribution / selectivity;

Downstream raw materials:

2-(4-fluorophenyl)-N-methyl-5-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)benzofuran-3-carboxamide

C₃₄H₃₉N₃O₅

N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)quinazolin-4-amine

Refernces