3'-DEOXY-5'-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE

Base Information

• Chemical Name: 3'-DEOXY-5'-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE
• CAS No.: 114551-15-4
• Molecular Formula: C31H32 N2 O7
• Molecular Weight: 544.59
• Mol file: 114551-15-4.mol

Synonyms:3’-DEOXY-5’-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE

Chemical Property of 3'-DEOXY-5'-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE

Chemical Property:

• PSA: 112.01000
• LogP: 3.51930

Purity/Quality:

99%min ^*data from raw suppliers

5''-O-(Dimethoxytrityl)-5-methyl-3''-deoxyuridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5''-O-(Dimethoxytrityl)-5-methyl-3''-deoxyuridine can be used as reactant/reagent in preparation of binding competent oligomers containing unsaturated 3'',?5'' and 2'',?5'' linkages and related compounds.

Technology Process of 3'-DEOXY-5'-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE

There total 16 articles about 3'-DEOXY-5'-O-(DIMETHOXYTRITYL)-5-METHYLURIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(3-deoxy-β-D-threo-pentofuranosyl)thymine (114672-74-1) → 5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)thymine (114551-15-4)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1081/NCN-200033912

Reference yield: 75.0%

5'-O-(4,4'-dimethoxytrityl)-1-(2,3-anhydro-β-D-lyxofuranosyl)thymine (114551-08-5) → 5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)thymine (114551-15-4)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h;

DOI:10.1021/jm00402a038

Reference yield:

C31H30N2O6 → 5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)thymine (114551-15-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 3h;

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-1-(2,3-anhydro-β-D-lyxofuranosyl)thymine

4,4'-dimethoxytrityl chloride

1-(3-deoxy-β-D-threo-pentofuranosyl)thymine

1,2-di-O-acetyl-5-O-(methoxycarbonyl)-3-deoxy-D-erythro-pentofuranose

Downstream raw materials:

1-(3-deoxy-β-D-threo-pentofuranosyl)thymine

C₄₆H₅₂N₄O₁₂S

C₄₂H₄₆N₄O₁₁S

1-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-mercapto-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Refernces

• 1、 Rejman, Dominik,Masojidkova, Milena,Rosenberg, Ivan. "Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides". . p. 1683 - 1705. Retrieved 2007/10/03.