2-phenyl-7-bromobenzo[b]furan

Base Information

• Chemical Name: 2-phenyl-7-bromobenzo[b]furan
• CAS No.: 937716-80-8
• Molecular Formula: C₁₄H₉BrO
• Molecular Weight: 273.129
• Mol file: 937716-80-8.mol

Synonyms:2-phenyl-7-bromobenzo[b]furan

Chemical Property of 2-phenyl-7-bromobenzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-7-bromobenzo[b]furan

There total 9 articles about 2-phenyl-7-bromobenzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-dibromo-3-(phenoxymethyl)benzene + benzaldehyde (100-52-7) → 2-phenyl-7-bromobenzo[b]furan (937716-80-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 50 ℃; for 1h; Schlenk technique;

DOI:10.1021/acs.orglett.8b01207

Reference yield: 80.0%

(E)-1-phenylethanone O-(2-bromophenyl)oxime (937716-67-1) → 2-phenyl-7-bromobenzo[b]furan (937716-80-8)

Guidance literature:

With dmap; trifluoroacetyl triflate; In dichloromethane; at 20 ℃; for 22h;

DOI:10.1002/ejoc.200601001

Reference yield: 27.0%

2,6-dibromophenol (608-33-3) + phenylacetylene (536-74-3) → 2-phenyl-7-bromobenzo[b]furan (937716-80-8)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc00815d

upstream raw materials:

(E)-1-phenylethanone O-(2-bromophenyl)oxime

2,6-dibromophenol

phenylacetylene

benzoyl chloride

Refernces

• 1、 Delogu, Giovanna L.,Matos, Maria J.,Fanti, Maura,Era, Benedetta,Medda, Rosaria,Pieroni, Enrico,Fais, Antonella,Kumar, Amit,Pintus, Francesca. "2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling". . p. 2308 - 2313. Retrieved 2016/04/20.
• 2、 Takeda, Norihiko,Miyata, Okiko,Naito, Takeaki. "Efficient synthesis of benzofurans utilizing [3,3]-sigmatropic rearrangement triggered by N-trifluoroacetylation of oxime ethers: Short synthesis of natural 2-arylbenzofurans". . p. 1491 - 1509. Retrieved 2008/09/19.