Technology Process of methyl 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoate
There total 7 articles about methyl 3-(2-fluoro-4-((2-((methylsulfonyl)methyl)phenyl)ethynyl)phenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
water;
at 80 ℃;
Inert atmosphere;
DOI:10.1021/ml4000673
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate; triphenylphosphine / water / 20 °C
2: sodium tetrahydroborate; cobalt(II) chloride / methanol / Inert atmosphere
3: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
4: potassium carbonate / 3 h / 20 °C
5: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
With
sodium tetrahydroborate; copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; cobalt(II) chloride; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
methanol; water;
1: |Wittig Olefination / 3: |Sonogashira Cross-Coupling / 5: |Sonogashira Cross-Coupling;
DOI:10.1021/ml4000673