Multi-step reaction with 6 steps
1: sodium hydrogencarbonate; triphenylphosphine / water / 20 °C
2: sodium tetrahydroborate; cobalt(II) chloride / methanol / Inert atmosphere
3: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
4: potassium carbonate / 3 h / 20 °C
5: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
6: lithium hydroxide / water; tetrahydrofuran / 20 °C
With
sodium tetrahydroborate; copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; cobalt(II) chloride; lithium hydroxide; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
tetrahydrofuran; methanol; water;
1: |Wittig Olefination / 3: |Sonogashira Cross-Coupling / 5: |Sonogashira Cross-Coupling;
DOI:10.1021/ml4000673