Z-ARG(TOS)-OH CHA

Base Information

• Chemical Name: Z-ARG(TOS)-OH CHA
• CAS No.: 13650-38-9
• Molecular Formula: C21H26 N4 O6 S
• Molecular Weight: 462.527
• Mol file: 13650-38-9.mol

Synonyms:Ornithine,N2-carboxy-N5-[(p-tolylsulfonyl)amidino]-, N-benzyl ester (6CI,7CI); Ornithine,N2-carboxy-N5-[(p-tolylsulfonyl)amidino]-, N2-benzyl ester, L- (8CI); Na-Benzyloxycarbonyl-Nw-tosyl-L-arginine

Chemical Property of Z-ARG(TOS)-OH CHA

Chemical Property:

• Melting Point: 86-88℃
• PSA: 166.06000
• LogP: 4.31070
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%Min ^*data from raw suppliers

Z-Arg(Tos)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-ARG(TOS)-OH CHA

There total 2 articles about Z-ARG(TOS)-OH CHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Z-Arg-OH (1234-35-1) + p-toluenesulfonyl chloride (98-59-9) → Nα-Benzyloxycarbonyl-Nω-tosyl-L-arginin (13650-38-9)

Guidance literature:

alkline solution;

Reference yield:

→ Nα-Benzyloxycarbonyl-Nω-tosyl-L-arginin (13650-38-9)

Guidance literature:

entspr. Cyclohexylamin-Salz;

Reference yield: 98.0%

Nα-Benzyloxycarbonyl-Nω-tosyl-L-arginin (13650-38-9) + H-Pro-Pro-Gly-OEt*HBr → Z-Arg(Tos)-Pro-Pro-Gly-OEt

Guidance literature:

With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00181a012

upstream raw materials:

Z-Arg-OH

p-toluenesulfonyl chloride

Downstream raw materials:

N^α-Carbobenzoxy-N^G-tosyl-Arg-N^G-tosyl-Arg-δ-amino-valeriansaeuremethylester

N--urea

Z-Arg(Tos)-Val-NHNHBoc

Z-Arg(Tos)-MeArg(Tos)-MeIle-OBu

Refernces

• 1、 Matsamura, Eiko,Yamamoto, Eiko,Kawano, Tatsu,Shin, Takashi,Murao, Sawao. "Isolation and characterization of Nα-Benzyloxycarbonyl amino Acid Urethane Hydrolase II from Lactobacillus fermenti 36 ATCC 9338". . p. 1563 - 1572. Retrieved 2007/10/02.