6-Bromo-2,3-dihydrobenzofuran

Base Information

• Chemical Name: 6-Bromo-2,3-dihydrobenzofuran
• CAS No.: 189035-22-1
• Molecular Formula: C8H7 Br O
• Molecular Weight: 199.047
• Hs Code.: 2932999099
• European Community (EC) Number: 818-008-5
• DSSTox Substance ID: DTXSID60460146
• Nikkaji Number: J1.704.383H
• Wikidata: Q82284079
• Mol file: 189035-22-1.mol

Synonyms:6-bromo-2,3-dihydrobenzofuran;189035-22-1;6-BROMO-2,3-DIHYDRO-1-BENZOFURAN;Benzofuran, 6-bromo-2,3-dihydro-;6-BROMO-2,3-DIHYDRO-BENZOFURAN;MFCD08704305;6-BROMO-2,3-DIHYDROBENZO[B]FURAN;SCHEMBL267355;DTXSID60460146;BQWBDYZMUCSEHK-UHFFFAOYSA-N;AKOS006288569;MB06567;6-Bromo-2 pound not3-dihydrobenzofuran;CS-11601;SY026135;CS-0043071;EN300-113648;A880479;Z1198181832

Chemical Property of 6-Bromo-2,3-dihydrobenzofuran

Chemical Property:

• Vapor Pressure: 0.0607mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 239.8°C at 760 mmHg
• Flash Point: 94.9°C
• PSA: 9.23000
• Density: 1.582g/cm³
• LogP: 2.38400
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 197.96803
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2,3-dihydrobenzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C1C=CC(=C2)Br
• Uses: 6-Bromo-2,3-dihydrobenzofuran is used in the preparation of 2-alkylamino nicotinamide analogs as orally active ghrelin receptor (ghrelinR) inverse agonists.

Technology Process of 6-Bromo-2,3-dihydrobenzofuran

There total 7 articles about 6-Bromo-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-dibromo-2-(2-bromoethoxy)benzene (377091-18-4) → 6-bromo-2,3-dihydro-1-benzofuran (189035-22-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

Reference yield: 85.5%

→ 6-bromo-2,3-dihydro-1-benzofuran (189035-22-1)

Guidance literature:

Reference yield: 40.0%

1,4-dibromo-2-hydroxyethoxybenzene (377091-17-3) → 6-bromo-2,3-dihydro-1-benzofuran (189035-22-1)

Guidance literature:

1,4-dibromo-2-hydroxyethoxybenzene; With phosphorus tribromide; In toluene; at 90 ℃; for 2.5h; Heating / reflux;

With sodium hydroxide; In water; toluene; at 20 ℃;

With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 0.5h;

upstream raw materials:

2.3-dihydrobenzofuran

1,4-dibromo-2-hydroxyethoxybenzene

1,4-dibromo-2-(2-bromoethoxy)benzene

2,5-dibromophenol

Downstream raw materials:

2,3-dihydro-1-benzofuran-6-carbaldehyde

{4-[(2R,3R)-3-[2-(2,3-dihydro-benzofuran-6-yl)-2-oxo-ethylsulfanyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetic acid tert-butyl ester

{4-[(2R,3R)-3-[2-(2,3-dihydro-benzofuran-6-yl)-2-oxo-ethylsulfanyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetic acid

1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one

Refernces

• 1、 -. "Heterocyclic compound". . . Retrieved 2016/10/08.
• 2、 -. "COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF". . . Retrieved 2015/06/24.