WKYMVM

Base Information

• Chemical Name: WKYMVM
• CAS No.: 187986-17-0
• Molecular Formula: C₄₁H₆₁N₉O₇S₂
• Molecular Weight: 856.123
• Mol file: 187986-17-0.mol

Synonyms:1: PN:US20040220268 PAGE: 9 claimed protein;

Chemical Property of WKYMVM

Chemical Property:

• Boiling Point: 1269.6 °C at 760 mmHg
• PKA: 9.82±0.15(Predicted)
• Flash Point: 721.6 °C
• PSA: 321.46000
• Density: 1.268 g/cm³
• LogP: 5.14090
• Storage Temp.: -20°C
• Solubility.: H2O: >2mg/mL

Purity/Quality:

98%Min ^*data from raw suppliers

WKYMVm ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: WKYMVm is a lipoxin A4 receptor and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.

Technology Process of WKYMVM

There total 6 articles about WKYMVM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-D-Lys(BOC)-OH (92122-45-7) + Nα-fluorenyl-9-methoxycarbonyl-D-Met (71989-28-1,144701-23-5,112883-40-6) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) + Fmoc-D-Tyr(O-tBu)-OH (118488-18-9,204384-67-8) + 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan (163619-04-3) → wkymvm-NH2 (187986-11-4,187986-17-0)

Guidance literature:

Nα-fluorenyl-9-methoxycarbonyl-D-Met; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; MBHA link amide resin Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; MBHA link amide resin Automated synthesizer;

Fmoc-D-Lys(BOC)-OH; Nα-fluorenyl-9-methoxycarbonyl-D-Met; N-(9-fluorenylmethoxycarbonyl)-D-valine; Fmoc-D-Tyr(O-tBu)-OH; 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan; Further stages;

Reference yield:

C39H59NO15 + Fmoc-D-Lys(BOC)-OH (92122-45-7) + Nα-fluorenyl-9-methoxycarbonyl-D-Met (71989-28-1,144701-23-5,112883-40-6) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) + Fmoc-D-Tyr(O-tBu)-OH (118488-18-9,204384-67-8) + 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan (163619-04-3) → wkymvm-NH2 (187986-11-4,187986-17-0)

Guidance literature:

Nα-fluorenyl-9-methoxycarbonyl-D-Met; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; MBHA link amide resin Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; MBHA link amide resin Automated synthesizer;

C₃₉H₅₉NO₁₅; Fmoc-D-Lys(BOC)-OH; Nα-fluorenyl-9-methoxycarbonyl-D-Met; N-(9-fluorenylmethoxycarbonyl)-D-valine; Fmoc-D-Tyr(O-tBu)-OH; 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan; Further stages;

Reference yield:

C39H59NO15 + Fmoc-D-Lys(BOC)-OH (92122-45-7) + Nα-fluorenyl-9-methoxycarbonyl-D-Met (71989-28-1,144701-23-5,112883-40-6) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) + (2S,3S)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylic acid (33224-01-0) + Fmoc-D-Tyr(O-tBu)-OH (118488-18-9,204384-67-8) + 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan (163619-04-3) → wkymvm-NH2 (187986-11-4,187986-17-0)

Guidance literature:

Nα-fluorenyl-9-methoxycarbonyl-D-Met; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; MBHA link amide resin Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; MBHA link amide resin Automated synthesizer;

C₃₉H₅₉NO₁₅; Fmoc-D-Lys(BOC)-OH; Nα-fluorenyl-9-methoxycarbonyl-D-Met; N-(9-fluorenylmethoxycarbonyl)-D-valine; (2S,3S)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylic acid; Fmoc-D-Tyr(O-tBu)-OH; 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan; Further stages;

upstream raw materials:

Fmoc-Val-OH

Fmoc-Tyr(tBu)-OH

Fmoc-Lys(tert-butoxycarbonyl)

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Refernces