2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

Base Information

• Chemical Name: 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide
• CAS No.: 1418126-45-0
• Molecular Formula: C₂₆H₂₈FNO₄
• Molecular Weight: 437.511
• Mol file: 1418126-45-0.mol

Synonyms:2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

Chemical Property of 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

There total 6 articles about 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride (1418126-44-9) → 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide (1418126-45-0)

Guidance literature:

With sodium hydroxide; In chloroform; water; at 20 ℃; for 16h; Cooling with ice;

DOI:10.1002/chem.201201895

Reference yield:

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol (1418126-43-8) → 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide (1418126-45-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

2: bromic acid / water / 5 h / 105 °C

3: sodium iodide; potassium hydroxide / ethanol / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h / Inert atmosphere

5: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; In ethanol; chloroform; water; toluene;

DOI:10.1002/chem.201201895

Reference yield:

2-fluoro-5-methoxybenzaldehyde (105728-90-3) → 2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide (1418126-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / pH 1 / Inert atmosphere

2.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

3.1: bromic acid / water / 5 h / 105 °C

4.1: sodium iodide; potassium hydroxide / ethanol / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h / Inert atmosphere

6.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;

DOI:10.1002/chem.201201895

upstream raw materials:

N-methylhomoveratrylamine

2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol

2-fluoro-5-methoxybenzaldehyde

Downstream raw materials:

C₁₉H₂₂FNO₃

C₁₉H₂₀FNO₃

1-(5-(benzyloxy)-2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

3-((6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4-fluorophenol

Refernces