Technology Process of N-1-BENZYL-3-BENZYL-PIPERAZINE
There total 4 articles about N-1-BENZYL-3-BENZYL-PIPERAZINE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyl-3-(R)-benzyl piperazine-2,5-dione;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 21.75h;
Heating / reflux;
With
sodium hydroxide; water;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / methanol / 2.5 h / 0 - 20 °C
1.2: 18 h
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 21.75 h / 0 °C / Heating / reflux
With
lithium aluminium tetrahydride; thionyl chloride;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C
1.2: 20 h / 20 °C
2.1: thionyl chloride / methanol / 2.5 h / 0 - 20 °C
2.2: 18 h
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 21.75 h / 0 °C / Heating / reflux
With
lithium aluminium tetrahydride; thionyl chloride; 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; dichloromethane;
