Multi-step reaction with 10 steps
1.1: 60 percent / polyphosphate ester / 120 °C
2.1: 90 percent / K2CO3; KI / dimethylformamide / 20 - 50 °C
3.1: 71 percent / NaNO3; H2SO4 / 0 °C
4.1: N-bromosuccinimide; 2,2'-azobis(isobutyronitrile) / CCl4 / Heating
5.1: N,N-diisopropylethylamine / dimethylformamide / 20 °C
6.1: 96 percent / aq. HCl; Fe / ethanol / 0 °C
7.1: 98 percent / Et3N / CH2Cl2 / 1 h / 20 °C
8.1: Me3Al; N,N-diisopropylethylamine / CH2Cl2; hexane / 0 °C
8.2: 94 percent / CH2Cl2; hexane / 0 °C
9.1: 75 percent / dioxane / 0 °C
10.1: 79 percent / aq. NaOH / methanol / 1 h / 60 °C
With
hydrogenchloride; sodium hydroxide; sodium nitrate; N-Bromosuccinimide; polyphosphate ester; 2,2'-azobis(isobutyronitrile); sulfuric acid; trimethylaluminum; iron; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide;
In
1,4-dioxane; methanol; tetrachloromethane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0512894