4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE

Base Information

• Chemical Name: 4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE
• CAS No.: 453-34-9
• Molecular Formula: C₄H₆F₃NO₂
• Molecular Weight: 157.092
• Hs Code.: 2924199090
• Mol file: 453-34-9.mol

Synonyms:Butyramide,4,4,4-trifluoro-3-hydroxy- (8CI)

Chemical Property of 4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE

Chemical Property:

• Vapor Pressure: 0.00654mmHg at 25°C
• Refractive Index: 1.391
• Boiling Point: 240.6°Cat760mmHg
• Flash Point: 99.3°C
• PSA: 63.32000
• Density: 1.432g/cm³
• LogP: 0.48530

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4,4,4-Trifluoro-3-hydroxybutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE

There total 1 articles about 4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

ethyl 3-hydroxy-4,4,4-trifluorobutyrate (372-30-5) → 4,4,4-trifluoro-3-hydroxybutanamide (453-34-9)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃;

Reference yield: 83.43%

4,4,4-trifluoro-3-hydroxybutanamide (453-34-9) → 1-amino-3-hydroxy-4,4,4-trifluorobutane (57165-84-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

4,4,4-trifluoro-3-hydroxybutanamide (453-34-9) → rac-4,4,4-trifluoro-3-hydroxybutanoic acid (86884-21-1,108211-36-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01181a041

upstream raw materials:

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

Downstream raw materials:

3-amino-1,1,1-trifluoropropan-2-ol

rac-4,4,4-trifluoro-3-hydroxybutanoic acid

1-amino-3-hydroxy-4,4,4-trifluorobutane

Refernces

• 1、 -. "HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR". Page/Page column 114. . Retrieved 2021/09/04.
• 2、 -. "CONDENSED HETEROCYCLIC DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC DISEASES". Page/Page column 70; 71. . Retrieved 2019/03/12.