3-AMINO-1,1,1-TRIFLUORO-2-PROPANOL

Base Information

• Chemical Name: 3-AMINO-1,1,1-TRIFLUORO-2-PROPANOL
• CAS No.: 431-38-9
• Molecular Formula: C3H6 F3 N O
• Molecular Weight: 129.082
• Hs Code.: 2922199090
• Mol file: 431-38-9.mol

Synonyms:2-Amino-1-(trifluoromethyl)ethanol;2-Hydroxy-2-(trifluoromethyl)ethylamine; 2-Hydroxy-3,3,3-trifluoropropylamine;3-Amino-1,1,1-trifluoro-2-propanol

Chemical Property of 3-AMINO-1,1,1-TRIFLUORO-2-PROPANOL

Chemical Property:

• Vapor Pressure: 0.0308mmHg at 25°C
• Melting Point: 99°C
• Boiling Point: 176.5°Cat760mmHg
• PKA: 10.14±0.35(Predicted)
• Flash Point: 60.5°C
• PSA: 46.25000
• Density: 1.344g/cm³
• LogP: 0.56860
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

3-Amino-1,1,1-trifluoropropan-2-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 34-52-41-37/38
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-1,1,1-TRIFLUORO-2-PROPANOL

There total 6 articles about 3-AMINO-1,1,1-TRIFLUORO-2-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1,1,1-trifluoro-2,3-epoxypropane (359-41-1) → 3-amino-1,1,1-trifluoropropan-2-ol (431-38-9)

Guidance literature:

With ammonia; In water; at 20 ℃; for 22h;

Reference yield:

1,1,1-trifluoro-3-nitro-2-propanol (453-35-0) → 3-amino-1,1,1-trifluoropropan-2-ol (431-38-9)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1021/ja01630a022

Reference yield:

4,4,4-trifluoro-3-hydroxybutanamide (453-34-9) → 3-amino-1,1,1-trifluoropropan-2-ol (431-38-9)

Guidance literature:

With potassium hypochlorite; water; at 0 ℃; zuletzt unter Erwaermen;

DOI:10.1021/ja01181a041

upstream raw materials:

1,1,1-trifluoro-2,3-epoxypropane

4,4,4-trifluoro-3-hydroxybutanamide

1,1,1-trifluoro-3-nitro-2-propanol

Downstream raw materials:

N-acetyl-L-phenylalanyl-1-amino-3,3,3-trifluoropropan-2-ol

2,2,2-trifluoro-1-{[(2,4,6-trimethylbenzenesulfonyl)amino]methyl}ethyl 2,4,6-trimethylbenzenesulfonate

1-phenyl-3-(3,3,3-trifluoro-2-hydroxypropyl)thiourea

N-((1R,3S)-3-hydroxycyclohexyl)-4-((3,3,3-trifluoro-2-hydroxypropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Refernces

• 1、 Ellis, J. Michael,Altman, Michael D.,Bass, Alan,Butcher, John W.,Byford, Alan J.,Donofrio, Anthony,Galloway, Sheila,Haidle, Andrew M.,Jewell, James,Kelly, Nancy,Leccese, Erica K.,Lee, Sandra,Maddess, Matthew,Miller, J. Richard,Moy, Lily Y.,Osimboni, Ekundayo,Otte, Ryan D.,Reddy, M. Vijay,Spencer, Kerrie,Sun, Binyuan,Vincent, Stella H.,Ward, Gwendolyn J.,Woo, Grace H. C.,Yang, Chiming,Houshyar, Hani,Northrup, Alan B.. "Overcoming mutagenicity and ion channel activity: Optimization of selective spleen tyrosine kinase inhibitors". supporting information. p. 1929 - 1939. Retrieved 2015/04/27.
• 2、 -. "COMPOUNDS". Page/Page column 73-74. . Retrieved 2008/12/04.